Health Innovations via Engineering (HIVE) is a community of expert health engineers bound in a virtual core by their vision to address the grand challenges of medicine by engineering technological solutions.

HIVE aims to bring together engineers from across UCSF departments and schools—Dentistry, Medicine, Nursing and Pharmacy—to develop and apply engineering approaches to improve human health. This initiative builds on the talent of engineering-based faculty across the institution by providing opportunities to connect, collaborate, and address unsolved challenges at the intersection of engineering and health.

 

Community of Engineers 

Tejal Desai, PhD

Department Chair & Professor
Bioengineering

Tejal Desai is the Ernest L. Prien Endowed Professor and Chair of the Department of Bioengineering and Therapeutic Sciences within the Schools of Pharmacy and Medicine at the University of California, San Francisco (UCSF); the director of the NIH training grant for the Joint Graduate Program in Bioengineering at the University of California, Berkeley (UCB) and UCSF; and the founding director of the UCSF/UC Berkeley Master’s Program in Translational Medicine.

Tamara Alliston, PhD

Professor
Orthopaedic Surgery

Dr. Tamara Alliston is a Professor in the Department of Orthopaedic Surgery and is co-Director of the Skeletal Biology Core of the Center of Musculoskeletal Biology and Medicine. Her research focuses on the mechanobiologic pathways controlling stem cell and skeletal cell differentiation in bone and cartilage, seeking to understand how these pathways maintain the mechanical integrity of the healthy skeleton, and how this is disrupted in skeletal diseases like arthritis and osteoporosis. In particular, she studies the mechanobiology of TGFß in the skeleton.

Mekhail Anwar, MD, PhD

Assistant Professor
Radiation Oncology

Mekhail Anwar, M.D., Ph.D., is an Assistant Professor in the Department of Radiation Oncology at the University of California, San Francisco, with expertise in electrical engineering focusing on integrated circuits and micro-fabricated sensors for cancer imaging with a clinical practice in Radiation Oncology specializing in the multimodality treatment of malignancies using focal, targeted radiation therapy.

Edward Chang, MD

Professor
Neurological Surgery

Dr. Edward Chang is Professor of Neurological Surgery and co-Director of the Center for Neural Engineering at UC Berkeley and San Francisco. Dr. Chang’s clinical expertise is surgical therapies for intractable epilepsy, trigeminal neuralgia, pain, hemifacial spasm, and adult brain tumors.

Hana El-Samad, PhD

Professor
Biochemistry and Biophysics

Dr. Hana El-Samad is the Kuo Family Endowed Professor and vice-chair in the Department of Biochemistry and Biophysics in the UCSF School of Medicine. She earned a PhD in mechanical engineering at UC Santa Barbara, studying control theory and dynamical systems, where her work examined things like robots and automobile cruise control, and how they function to generate robust operation in uncertain environments. Dr. El-Samad has applied these theories and mathematical tools to biology. She and her lab are focused on tackling fundamental challenges in the precise measurement and analysis of decision making in complex biological networks.

Zev Gartner, PhD

Professor
Pharmaceutical Chemistry

Dr. Zev Gartner is a Professor in the Department of Pharmaceutical Chemistry and is co-Director of the UCSF-based, multi-institution Center for Cellular Construction. He graduated from UC Berkeley and earned his PhD in Chemistry from Harvard University in 2004. He is working to understand how cells assemble into multicellular tissues; how the structure of tissues coordinate the behavior of individual cells; and how changes to tissue structure drive the progression of diseases like cancer. Toward these goals, he and his lab build, perturb, and model human tissues in vitro using techniques from the chemical, engineering, physical and biological sciences.

Sunita Ho, MS, PhD

Professor
Preventive & Restorative Dental Sciences

Dr. Sunita Ho is a bioengineer who focuses on studies related to biomineralization, biomechanics, and biomaterials. She is a Professor in the Department of Urology, School of Medicine, and in the Department of Preventive and Restorative Dental Sciences (PRDS), School of Dentistry. Dr. Ho focuses on site-specific interventions to mitigate the beginnings of pathologic formations of biomaterials in humans. She investigates the regenerative aspects of soft and hard tissue attachments within craniofacial and musculoskeletal joints. Using biomechanics and mechanobiological approaches, Dr. Ho maps the special and temporal aspects of “mechano-responsiveness.”

Jeffrey Lotz, PhD

Professor
Orthopaedic Surgery

Dr. Jeffrey Lotz, Ph.D., holds the David S. Bradford, MD, Endowed Chair in Orthopaedic Surgery and vice chair for research. He has earned several awards for spine research, and serves as a deputy editor for the journal, Spine. Dr. Lotz is the founding director of the UCSF Core Center for Musculoskeletal Biology in Medicine and the NSF Center for Disruptive Musculoskeletal Innovations, and corresponding PI for the newly established Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration (C-DOCTOR). He has expertise in spine biomechanics, intervertebral disc biology, and tissue engineering.

Todd Mcdevitt, PhD

Professor
Bioengineering

Dr. Todd McDevitt’s research focuses on engineering technologies that direct the differentiation and morphogenesis of stem cells into functional tissue constructs. The lab is working to create human tissue models that can be used to study development and new approaches to treat multiple diseases that afflict the cardiovascular, neurological, immunological, and musculoskeletal systems.

Shuvo Roy, PhD

Professor
Bioengineering

Dr. Shuvo Roy is a UCSF bioengineer working on the world’s first implantable bio-artificial kidney. His focus is on medical device development to address unmet clinical needs by leveraging his background in microelectromechanical systems (MEMS) along with advances in biomaterials, electronics, and nanotechnology to advance health worldwide. He is a professor in the Department of Bioengineering and Therapeutic Sciences and the Director of the Biodesign Laboratory, along with an adjunct appointment in the Department of Surgery. In addition, Dr. Roy serves as the Technical Director of The Kidney Project and is a founding member of the FDA-supported UCSF-Stanford Pediatric Device Consortium. 

Seth Shipman, PhD

Assistant Professor
Bioengineering

Dr. Seth Shipman's research focuses on cellular systems in the midst of change. His lab seeks to better understand how the order of transcriptional events during development can drive changes in cell fate, and to better intervene in diseases characterized by change, like progressive neurodegeneration and cancer. His lab takes a molecular engineering approach, leveraging the versatility of DNA as a programmable biological polymer to gather data without destroying cells, and deliver therapeutics that can modify their effect based on cell context.

Valerie Weaver, PhD

Professor
Surgery

Dr. Weaver is a professor in the Department of Surgery and the director of the Center for Bioengineering and Tissue Regeneration. Her research focuses on the contribution of force, cell-intrinsic as well as extracellular matrix, to oncogenesis and tumor development. Dr. Weaver and her lab employ 2- and 3-D in-vitro cell culture techniques, clinical samples and animal models with force application techniques, traction force and atomic force microscopy to assess the influence of the mechanical aspects of the cell environment on cell behavior and tumor progression.