Shuvo Roy, PhD

Professor

Bioengineering

+1 415 514-9666

Dr. Shuvo Roy is a UCSF bioengineer working on the world’s first implantable bio-artificial kidney. His focus is on medical device development to address unmet clinical needs by leveraging his background in microelectromechanical systems (MEMS) along with advances in biomaterials, electronics, and nanotechnology to advance health worldwide. He is a professor in the Department of Bioengineering and Therapeutic Sciences and the Director of the Biodesign Laboratory, along with an adjunct appointment in the Department of Surgery. In addition, Dr. Roy serves as the Technical Director of The Kidney Project and is a founding member of the FDA-supported UCSF-Stanford Pediatric Device Consortium.

Dr. Royis the Engineering Lead for UCSF Surgical Innovations, which identifies, mentors and facilitates the translation of medical technologies into transformative new devices and treatments to improve human health. He teaches a bioengineering course on translational challenges for medical devices and diagnostics, and currently acts as the Faculty Director of the UCSF-UCB Master of Translational Medicine (MTM) program.

Dr. Roy earned a BS degree, magna cum laude, for triple majors in physics, mathematics, and computer science, from Mount Union College in Alliance, Ohio in 1992. In 1995, he earned an MS in electrical engineering and applied physics and, in 2001, he earned a Ph.D. in electrical engineering and computer science, both from Case Western Reserve University in Cleveland, Ohio. He is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) and a recipient of the FDA’s Innovation Pathway 2.0 Award

Publications:

An arteriovenous mock circulatory loop and accompanying bond graph model for in vitro study of peripheral intravascular bioartificial organs.

Artificial organs

Moyer JC, Chivukula VK, Taheri-Tehrani P, Sandhu S, Blaha C, Fissell WH, Roy S

Patient Preference Trade-offs for Next-Generation Kidney Replacement Therapies.

Clinical journal of the American Society of Nephrology : CJASN

Wilson L, Gress AF, Frassetto L, Sarathy H, Gress EA, Fissell WH, Roy S

Renal Embolization-Induced Uremic Swine Model for Assessment of Next-Generation Implantable Hemodialyzers.

Toxins

Moyer J, Wilson MW, Sorrentino TA, Santandreu A, Chen C, Hu D, Kerdok A, Porock E, Wright N, Ly J, Blaha C, Frassetto LA, Fissell WH, Vartanian SM, Roy S

Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes.

Nature communications

Kim EJ, Chen C, Gologorsky R, Santandreu A, Torres A, Wright N, Goodin MS, Moyer J, Chui BW, Blaha C, Brakeman P, Vartanian S, Tang Q, David Humes H, Fissell WH, Roy S

Characterization of human islet function in a convection-driven intravascular bioartificial pancreas.

Bioengineering & translational medicine

Santandreu AG, Taheri-Tehrani P, Feinberg B, Torres A, Blaha C, Shaheen R, Moyer J, Wright N, Szot GL, Fissell WH, Vartanian S, Posselt A, Roy S

Silicon membranes for extracorporeal life support: a comparison of design and fabrication methodologies.

Biomedical microdevices

Blauvelt DG, Chui BW, Higgins NC, Baltazar FJ, Roy S

Inhibition of Transforming Growth Factor-� Improves Primary Renal Tubule Cell Differentiation in Long-Term Culture.

Tissue engineering. Part A

Hunter K, Larsen JA, Love HD, Evans RC, Roy S, Zent R, Harris RC, Wilson MH, Fissell WH

Functionalizing Polyacrylamide Hydrogels for Renal Cell Culture Under Fluid Shear Stress.

Tissue engineering. Part A

Love H, Evans R, Hunter K, Roy S, Fissell WH

Wearable and implantable artificial kidney devices for end-stage kidney disease treatment-Current status and review.

Artificial organs

Groth T, Stegmayr BG, Ash SR, Kuchinka J, Wieringa FP, Fissell WH, Roy S

The Advancing American Kidney Health Initiative: The Challenge of Overcoming the Status Quo.

Journal of the American Society of Nephrology : JASN

Conway PT, Gedney N, Roy S, Fissell WH

Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived ß cells for intravascular bioartificial pancreas applications.

Journal of biomedical materials research. Part A

Shaheen R, Gurlin RE, Gologorsky R, Blaha C, Munnangi P, Santandreu A, Torres A, Carnese P, Nair GG, Szot G, Fissell WH, Hebrok M, Roy S

Opportunities for Regulatory Changes to Promote Pediatric Device Innovation in the United States: Joint Recommendations From Pediatric Innovator Roundtables.

IEEE journal of translational engineering in health and medicine

Sanger T, Chang A, Feaster W, Taraman S, Afari N, Beauregard D, Dethlefs B, Ghere T, Kabeer M, Tolomiczenko G, Billig M, Brophy J, Eskandanian K, Espinoza J, Farrugia S, Harrison M, Horvat C, Hoyen C, Koh C, Komiyama A, Nelson K, Kulkarni O, Levy R, Maher K, O'Donnell M, Ponsky T, Richmond F, Richter J, Roy S, Samir S, Suresh S, Stallworth C, Thekkedath U, Toman K, Wall J, West L, Wolff D

Use of Ballistocardiography to Monitor Cardiovascular Hemodynamics in Preeclampsia.

Women's health reports (New Rochelle, N.Y.)

Quesada O, Shandhi MMH, Beach S, Dowling S, Tandon D, Heller J, Etemadi M, Roy S, Gonzalez Velez JM, Inan OT, Klein L

Advances in extracorporeal membrane oxygenator design for artificial placenta technology.

Artificial organs

Blauvelt DG, Abada EN, Oishi P, Roy S

Metformin and Inhibition of TGF-ß Stimulate In Vitro Transport in Primary Renal Tubule Cells.

Tissue engineering. Part A

Love HD, Evans RC, Humes HD, Roy S, Zent R, Harris R, Wilson MH, Fissell WH

Treating the kidneys - a new era in the United States (and beyond).

Nature reviews. Nephrology

Fissell WH, Roy S

Ambulatory Hemodialysis-Technology Landscape and Potential for Patient-Centered Treatment.

Clinical journal of the American Society of Nephrology : CJASN

Hojs N, Fissell WH, Roy S

Endovascular Ion Exchange Chemofiltration Device Reduces Off-Target Doxorubicin Exposure in a Hepatic Intra-arterial Chemotherapy Model.

Radiology. Imaging cancer

Yee C, McCoy D, Yu J, Losey A, Jordan C, Moore T, Stillson C, Oh HJ, Kilbride B, Roy S, Patel A, Wilson MW, Hetts SW

Genome Engineering Renal Epithelial Cells for Enhanced Volume Transport Function.

Cellular and molecular bioengineering

Wilson MH, Veach RA, Luo W, Welch RC, Roy S, Fissell WH

Ultrafiltration for management of fluid overload in patients with heart failure.

Artificial organs

Gologorsky RC, Roy S

Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture.

Tissue engineering. Part A

Love HD, Ao M, Jorgensen S, Swearingen L, Ferrell NJ, Evans RC, Gewin L, Harris RC, Zent R, Roy S, Fissell WH

In Vitro models for thrombogenicity testing of blood-recirculating medical devices.

Expert review of medical devices

Sarode DN, Roy S

Application of physiological shear stress to renal tubular epithelial cells.

Methods in cell biology

Ferrell N, Sandoval RM, Molitoris BA, Brakeman P, Roy S, Fissell WH

Compliance monitoring via a Bluetooth-enabled retainer: A prospective clinical pilot study.

Orthodontics & craniofacial research

Castle E, Chung P, Behfar MH, Chen M, Gao J, Chiu N, Nelson G, Roy S, Oberoi S

Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.

The Journal of pharmacology and experimental therapeutics

Jayagopal A, Brakeman PR, Soler P, Ferrell N, Fissell W, Kroetz DL, Roy S

In vitro and in vivo hemocompatibility assessment of ultrathin sulfobetaine polymer coatings for silicon-based implants.

Journal of biomaterials applications

Iqbal Z, Kim S, Moyer J, Moses W, Abada E, Wright N, Kim EJ, Park J, Fissell WH, Roy S

Orbital Shear Stress Regulates Differentiation and Barrier Function of Primary Renal Tubular Epithelial Cells.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Ferrell N, Cheng J, Miao S, Roy S, Fissell WH

Acoustic Methods for Pulmonary Diagnosis.

IEEE reviews in biomedical engineering

Rao A, Huynh E, Royston T, Kornblith A, Roy S

Evaluation of silicon membranes for extracorporeal membrane oxygenation (ECMO).

Biomedical microdevices

Abada EN, Feinberg BJ, Roy S

Innovations in Wearable and Implantable Artificial Kidneys.

American journal of kidney diseases : the official journal of the National Kidney Foundation

Salani M, Roy S, Fissell WH

Improved Detection of Lung Fluid With Standardized Acoustic Stimulation of the Chest.

IEEE journal of translational engineering in health and medicine

Rao A, Chu S, Batlivala N, Zetumer S, Roy S

Tabla: A Proof-of-Concept Auscultatory Percussion Device for Low-Cost Pneumonia Detection.

Sensors (Basel, Switzerland)

Rao A, Ruiz J, Bao C, Roy S

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.

Cell stem cell

Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M

Combined In Silico and In Vitro Approach Predicts Low Wall Shear Stress Regions in a Hemofilter that Correlate with Thrombus Formation In Vivo.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Buck AKW, Groszek JJ, Colvin DC, Keller SB, Kensinger C, Forbes R, Karp S, Williams P, Roy S, Fissell WH

Original article submission: Platelet stress accumulation analysis to predict thrombogenicity of an artificial kidney.

Journal of biomechanics

Buck AKW, Goebel SG, Goodin MS, Wright NJ, Groszek JJ, Moyer J, Singh S, Bluestein D, Fissell WH, Roy S

Novel Wearable Seismocardiography and Machine Learning Algorithms Can Assess Clinical Status of Heart Failure Patients.

Circulation. Heart failure

Inan OT, Baran Pouyan M, Javaid AQ, Dowling S, Etemadi M, Dorier A, Heller JA, Bicen AO, Roy S, De Marco T, Klein L

Slit pores preferred over cylindrical pores for high selectivity in biomolecular filtration.

Journal of colloid and interface science

Feinberg BJ, Hsiao JC, Park J, Zydney AL, Fissell WH, Roy S

Sterilization effects on ultrathin film polymer coatings for silicon-based implantable medical devices.

Journal of biomedical materials research. Part B, Applied biomaterials

Iqbal Z, Moses W, Kim S, Kim EJ, Fissell WH, Roy S

Silicon Micropore-Based Parallel Plate Membrane Oxygenator.

Artificial organs

Dharia A, Abada E, Feinberg B, Yeager T, Moses W, Park J, Blaha C, Wright N, Padilla B, Roy S

Correction: An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.

Lab on a chip

Song S, Blaha C, Moses W, Park J, Wright N, Groszek J, Fissell W, Vartanian S, Posselt AM, Roy S

An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.

Lab on a chip

Song S, Blaha C, Moses W, Park J, Wright N, Groszek J, Fissell W, Vartanian S, Posselt AM, Roy S

A distributed solute model: an extended two-pore model with application to the glomerular sieving of Ficoll.

American journal of physiology. Renal physiology

Öberg CM, Groszek JJ, Roy S, Fissell WH, Rippe B

Silicon nanoporous membranes as a rigorous platform for validation of biomolecular transport models.

Journal of membrane science

Feinberg BJ, Hsiao JC, Park J, Zydney AL, Fissell WH, Roy S

Glucose-Stimulated Insulin Response of Silicon Nanopore-Immunoprotected Islets under Convective Transport.

ACS biomaterials science & engineering

Song S, Yeung R, Park J, Posselt AM, Desai TA, Tang Q, Roy S

Evolution of Gas Permeable Membranes for Extracorporeal Membrane Oxygenation.

Artificial organs

Yeager T, Roy S

A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells.

Biomicrofluidics

Brakeman P, Miao S, Cheng J, Lee CZ, Roy S, Fissell WH, Ferrell N

Quantifying and Reducing Motion Artifacts in Wearable Seismocardiogram Measurements During Walking to Assess Left Ventricular Health.

IEEE transactions on bio-medical engineering

Javaid AQ, Ashouri H, Dorier A, Etemadi M, Heller JA, Roy S, Inan OT

Inductive passive sensor for intraparenchymal and intraventricular monitoring of intracranial pressure.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Behfar MH, Abada E, Sydanheimo L, Goldman K, Fleischman AJ, Gupta N, Ukkonen L, Roy S

Diffusive Silicon Nanopore Membranes for Hemodialysis Applications.

PloS one

Kim S, Feinberg B, Kant R, Chui B, Goldman K, Park J, Moses W, Blaha C, Iqbal Z, Chow C, Wright N, Fissell WH, Zydney A, Roy S

First Implantation of Silicon Nanopore Membrane Hemofilters.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Kensinger C, Karp S, Kant R, Chui BW, Goldman K, Yeager T, Gould ER, Buck A, Laneve DC, Groszek JJ, Roy S, Fissell WH

Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport.

Scientific reports

Song S, Faleo G, Yeung R, Kant R, Posselt AM, Desai TA, Tang Q, Roy S

Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Kim S, Heller J, Iqbal Z, Kant R, Kim EJ, Durack J, Saeed M, Do L, Hetts S, Wilson M, Brakeman P, Fissell WH, Roy S

Progress and challenges in macroencapsulation approaches for type 1 diabetes (T1D) treatment: Cells, biomaterials, and devices.

Biotechnology and bioengineering

Song S, Roy S

MyPectus: First-in-human pilot study of remote compliance monitoring of teens using dynamic compression bracing to correct pectus carinatum.

Journal of pediatric surgery

Harrison B, Stern L, Chung P, Etemadi M, Kwiat D, Roy S, Harrison MR, Martinez-Ferro M

Corrigendum to: Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.

Journal of the mechanical behavior of biomedical materials

Yang J, Charif AC, Puskas JE, Phillips H, Shanahan KJ, Garsed J, Fleischman A, Goldman K, Roy S, Luebbers MT, Dombrowski SM, Luciano MG

A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables.

IEEE transactions on biomedical circuits and systems

Etemadi M, Inan OT, Heller JA, Hersek S, Klein L, Roy S

Impedance sensing device enables early detection of pressure ulcers in vivo.

Nature communications

Swisher SL, Lin MC, Liao A, Leeflang EJ, Khan Y, Pavinatto FJ, Mann K, Naujokas A, Young D, Roy S, Harrison MR, Arias AC, Subramanian V, Maharbiz MM

The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells.

Acta biomaterialia

Song S, Kim EJ, Bahney CS, Miclau T, Marcucio R, Roy S

Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.

Journal of the mechanical behavior of biomedical materials

Yang J, Charif AC, Puskas JE, Phillips H, Shanahan KJ, Garsed J, Fleischman A, Goldman K, Roy S, Luebbers MT, Dombrowski SM, Luciano MG

Current strategies and challenges in engineering a bioartificial kidney.

Frontiers in bioscience (Elite edition)

Kim S, Fissell WH, Humes DH, Roy S

Impedance sensing device for monitoring ulcer healing in human patients.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Liao A, Lin MC, Ritz LC, Swisher SL, Ni D, Mann K, Khan Y, Roy S, Harrison MR, Arias AC, Subramanian V, Young D, Maharbiz MM

Toward continuous, noninvasive assessment of ventricular function and hemodynamics: wearable ballistocardiography.

IEEE journal of biomedical and health informatics

Wiens AD, Etemadi M, Roy S, Klein L, Inan OT

Rapid and low-cost prototyping of medical devices using 3D printed molds for liquid injection molding.

Journal of visualized experiments : JoVE

Chung P, Heller JA, Etemadi M, Ottoson PE, Liu JA, Rand L, Roy S

Imaging assessment of a portable hemodialysis device: detection of possible failure modes and monitoring of functional performance.

Medical instrumentation (Luton, England)

Olorunsola OG, Kim SH, Chang R, Kuo YC, Hetts SW, Heller A, Kant R, Saeed M, Fissell WH, Roy S, Wilson MW

Miniaturizing RFID for magnamosis.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Jiang H, Chen S, Kish S, Loh L, Zhang J, Zhang X, Kwiat D, Harrison M, Roy S

Tracking clinical status for heart failure patients using ballistocardiography and electrocardiography signal features.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Etemadi M, Hersek S, Tseng JM, Rabbani N, Heller JA, Roy S, Klein L, Inan OT

Wearable ballistocardiography: preliminary methods for mapping surface vibration measurements to whole body forces.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Wiens A, Etemadi M, Klein L, Roy S, Inan OT

Microelectromechanical systems and nephrology: the next frontier in renal replacement technology.

Advances in chronic kidney disease

Kim S, Roy S

A low-frequency versatile wireless power transfer technology for biomedical implants.

IEEE transactions on biomedical circuits and systems

Jiang H, Zhang J, Lan D, Liou S, Shahnasser H, Fechter R, Hirose S, Harrison M, Roy S

Towards BirthAlert--A Clinical Device Intended for Early Preterm Birth Detection.

IEEE transactions on bio-medical engineering

Etemadi M, Chung P, Heller JA, Liu JA, Rand L, Roy S

Response of bone marrow derived connective tissue progenitor cell morphology and proliferation on geometrically modulated microtextured substrates.

Biomedical microdevices

Kim EJ, Fleischman AJ, Muschler GF, Roy S

The bioartificial kidney: current status and future promise.

Pediatric nephrology (Berlin, Germany)

Humes HD, Buffington D, Westover AJ, Roy S, Fissell WH

Achieving more frequent and longer dialysis for the majority: wearable dialysis and implantable artificial kidney devices.

Kidney international

Fissell WH, Roy S, Davenport A

Fabric-based pressure sensor array for decubitus ulcer monitoring.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Chung P, Rowe A, Etemadi M, Lee H, Roy S

Novel device to trend impedance and fluorescence of the cervix for preterm birth detection.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Etemadi M, Chung P, Heller JA, Liu J, Grossman-Kahn R, Rand L, Roy S

Implantable ultra-low pulmonary pressure monitoring system for fetal surgery.

IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society

Etemadi M, Heller JA, Schecter SC, Shue EH, Miniati D, Roy S

A feed-forward controlled AC-DC boost converter for biomedical implants.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Jiang H, Lan D, Lin D, Zhang J, Liou S, Shahnasser H, Shen M, Harrison M, Roy S