Jeffrey Lotz, PhD

Professor
Orthopaedic Surgery
+1 415 476-7881

Dr. Jeffrey Lotz, Ph.D., holds the David S. Bradford, MD, Endowed Chair in Orthopaedic Surgery and vice chair for research. He has earned several awards for spine research, and serves as a deputy editor for the journal, Spine. Dr. Lotz is the founding director of the UCSF Core Center for Musculoskeletal Biology in Medicine and the NSF Center for Disruptive Musculoskeletal Innovations, and corresponding PI for the newly established Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration (C-DOCTOR). He has expertise in spine biomechanics, intervertebral disc biology, and tissue engineering.

Dr. Lotz’s laboratory work focuses on identifying mechanisms of disc degeneration, developing novel diagnostics and therapies for low back pain, and the biomechanics of spinal instrumentation. He earned a doctorate degree in Medical Engineering from the Harvard/MIT Division of Health Sciences and Technology, a Master’s Degree in Mechanical Engineering Design from Stanford University, and Bachelor of Science in Mechanical Engineering from UC Berkeley. 

Publications: 

FDA Public Workshop: Orthopaedic Sensing, Measuring, and Advanced Reporting Technology (SMART) Devices.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Baumann AP, O'Neill C, Owens MC, Weber SC, Sivan S, D'Amico R, Carmody S, Bini S, Sawyer AJ, Lotz JC, Goel V, Dmitriev AE

Magnetic nanoparticles synergize with pulsed magnetic fields to stimulate osteogenesis in-vitro.

Tissue engineering. Part A

Habib M, Horne DA, Hussein K, Coughlin D, Waldorff EI, Zhang N, Ryaby JT, Lotz JC

Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes).

International journal of molecular sciences

Dudli S, Ballatori A, Bay-Jensen AC, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Heggli I, Juengel A, Karppinen J, Brunner F, Farshad M, Distler O, Lotz JC, Fields AJ

Reachable Workspace and Proximal Function Measures for Quantifying Upper Limb Motion.

IEEE journal of biomedical and health informatics

Matthew R, Seko S, Kurillo G, Bajcsy R, Cheng L, Han J, Lotz J

The effect of parity on age-related degenerative changes in sagittal balance.

Spine

Bailey JF, Sparrey CJ, Williams FMK, Curran PF, Lotz JC, Kramer PA

The Effect of Zoledronic Acid on Serum Biomarkers among Patients with Chronic Low Back Pain and Modic Changes in Lumbar Magnetic Resonance Imaging.

Diagnostics (Basel, Switzerland)

Koivisto K, Karppinen J, Haapea M, Järvinen J, Kyllönen E, Tervonen O, Niinimäki J, Alini M, Lotz J, Dudli S, Samartzis D, Risteli J, Majuri ML, Alenius H, Grad S

Pulsed electromagnetic fields reduce acute inflammation in the injured rat-tail intervertebral disc.

JOR spine

Chan AK, Tang X, Mummaneni NV, Coughlin D, Liebenberg E, Ouyang A, Dudli S, Lauricella M, Zhang N, Waldorff EI, Ryaby JT, Lotz JC

Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis.

Bone research

Mazur CM, Woo JJ, Yee CS, Fields AJ, Acevedo C, Bailey KN, Kaya S, Fowler TW, Lotz JC, Dang A, Kuo AC, Vail TP, Alliston T

Measuring and reporting of vertebral endplate bone marrow lesions as seen on MRI (Modic changes): recommendations from the ISSLS Degenerative Spinal Phenotypes Group.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Fields AJ, Battié MC, Herzog RJ, Jarvik JG, Krug R, Link TM, Lotz JC, O'Neill CW, Sharma A

The Relationship Between Endplate Pathology and Patient-Reported Symptoms for Chronic Low Back Pain Depends on Lumbar Paraspinal Muscle Quality.

Spine

Bailey JF, Fields AJ, Ballatori A, Cohen D, Jain D, Coughlin D, O'Neill C, McCormick Z, Han M, Krug R, Demir-Deviren S, Lotz JC

Functional workspace and patient-reported outcomes improve after reverse and total shoulder arthroplasty.

Journal of shoulder and elbow surgery

Ngan A, Xiao W, Curran PF, Tseng WJ, Hung LW, Nguyen C, Matthew R, Ma B, Lotz J, Feeley BT

Simple Spline Representation for Identifying Sit-to-Stand Strategies.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Matthew RP, Seko S, Bailey J, Bajcsy R, Lotz J

ISSLS PRIZE IN BIOENGINEERING SCIENCE 2019: biomechanical changes in dynamic sagittal balance and lower limb compensatory strategies following realignment surgery in adult spinal deformity patients.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Bailey JF, Matthew RP, Seko S, Curran P, Chu L, Berven SH, Deviren V, Burch S, Lotz JC

Estimating Sit-to-Stand Dynamics using a Single Depth Camera.

IEEE journal of biomedical and health informatics

Matthew RP, Seko S, Bailey J, Bajcsy R, Lotz J

Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI.

Journal of magnetic resonance imaging : JMRI

Krug R, Joseph GB, Han M, Fields A, Cheung J, Mundada M, Bailey J, Rochette A, Ballatori A, McCulloch CE, McCormick Z, O'Neill C, Link TM, Lotz J

Magnetic resonance spectroscopy (MRS) can identify painful lumbar discs and may facilitate improved clinical outcomes of lumbar surgeries for discogenic pain.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Gornet MG, Peacock J, Claude J, Schranck FW, Copay AG, Eastlack RK, Benz R, Olshen A, Lotz JC

Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section.

JOR spine

Smith LJ, Silverman L, Sakai D, Le Maitre CL, Mauck RL, Malhotra NR, Lotz JC, Buckley CT

Kinematic and Kinetic Validation of an Improved Depth Camera Motion Assessment System Using Rigid Bodies.

IEEE journal of biomedical and health informatics

Matthew RP, Seko S, Bajcsy R, Lotz J

Contribution of the endplates to disc degeneration.

Current molecular biology reports

Fields AJ, Ballatori A, Liebenberg EC, Lotz JC

Tidemark Avulsions are a Predominant Form of Endplate Irregularity.

Spine

Berg-Johansen B, Jain D, Liebenberg EC, Fields AJ, Link TM, O'Neill CW, Lotz JC

A functional method for generating individualized spine models from motion-capture data.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Seko S, Matthew RP, Bajcsy R, Lotz JC

Tracking Kinematic and Kinetic Measures of Sit to Stand using an Instrumented Spine Orthosis.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Matthew RP, Seko S, Bailey J, Bajcsy R, Lotz J

Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration.

Spine

Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC

Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care.

Journal of dental research

Giannobile WV, Chai Y, Chen Y, Healy KE, Klein O, Lane N, Longaker MT, Lotz JC, Mooney DJ, Sfeir CS, Urata M, Wagner WR, Wu BM, Kohn DH

Modic type 1 change is an autoimmune response that requires a proinflammatory milieu provided by the 'Modic disc'.

The spine journal : official journal of the North American Spine Society

Dudli S, Liebenberg E, Magnitsky S, Lu B, Lauricella M, Lotz JC

Dynamic imaging demonstrates that pulsed electromagnetic fields (PEMF) suppress IL-6 transcription in bovine nucleus pulposus cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Tang X, Alliston T, Coughlin D, Miller S, Zhang N, Waldorff EI, Ryaby JT, Lotz JC

From the international space station to the clinic: how prolonged unloading may disrupt lumbar spine stability.

The spine journal : official journal of the North American Spine Society

Bailey JF, Miller SL, Khieu K, O'Neill CW, Healey RM, Coughlin DG, Sayson JV, Chang DG, Hargens AR, Lotz JC

Structural vertebral endplate nomenclature and etiology: a study by the ISSLS Spinal Phenotype Focus Group.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Zehra U, Bow C, Lotz JC, Williams FMK, Rajasekaran S, Karppinen J, Luk KDK, C Battiê M, Samartzis D

Inflammatory response of disc cells against Propionibacterium acnes depends on the presence of lumbar Modic changes.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Dudli S, Miller S, Demir-Deviren S, Lotz JC

A Kinect-based movement assessment system: marker position comparison to Vicon.

Computer methods in biomechanics and biomedical engineering

Nichols JK, Sena MP, Hu JL, O'Reilly OM, Feeley BT, Lotz JC

Structure-function relationships at the human spinal disc-vertebra interface.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Berg-Johansen B, Fields AJ, Liebenberg EC, Li A, Lotz JC

Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice.

Endocrinology

Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA

Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis.

Scientific reports

Fowler TW, Acevedo C, Mazur CM, Hall-Glenn F, Fields AJ, Bale HA, Ritchie RO, Lotz JC, Vail TP, Alliston T

Low intensity pulsed ultrasound (LIPUS) for the treatment of intervertebral disc degeneration.

Proceedings of SPIE--the International Society for Optical Engineering

Horne D, Jones P, Salgaonkar V, Adams M, Ozilgen BA, Zahos P, Tang X, Liebenburg E, Coughlin D, Lotz J, Diederich C

ISSLS PRIZE IN BASIC SCIENCE 2017: Intervertebral disc/bone marrow cross-talk with Modic changes.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Dudli S, Sing DC, Hu SS, Berven SH, Burch S, Deviren V, Cheng I, Tay BKB, Alamin TF, Ith MAM, Pietras EM, Lotz JC

Lumbar Spine Paraspinal Muscle and Intervertebral Disc Height Changes in Astronauts After Long-Duration Spaceflight on the International Space Station.

Spine

Chang DG, Healey RM, Snyder AJ, Sayson JV, Macias BR, Coughlin DG, Bailey JF, Parazynski SE, Lotz JC, Hargens AR

Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Ouyang A, Cerchiari AE, Tang X, Liebenberg E, Alliston T, Gartner ZJ, Lotz JC

Propionibacterium acnes infected intervertebral discs cause vertebral bone marrow lesions consistent with Modic changes.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Dudli S, Liebenberg E, Magnitsky S, Miller S, Demir-Deviren S, Lotz JC

Implantation of juvenile human chondrocytes demonstrates no adverse effect on spinal nerve tissue in rats.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Külling FA, Liu JJ, Liebenberg E, Lotz JC

Pathobiology of Modic changes.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Dudli S, Fields AJ, Samartzis D, Karppinen J, Lotz JC

Pulsed electromagnetic field (PEMF) treatment reduces expression of genes associated with disc degeneration in human intervertebral disc cells.

The spine journal : official journal of the North American Spine Society

Miller SL, Coughlin DG, Waldorff EI, Ryaby JT, Lotz JC

The effect of simulated microgravity on lumbar spine biomechanics: an in vitro study.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Laws CJ, Berg-Johansen B, Hargens AR, Lotz JC

A mechanical pivot-shift device for continuously applying defined loads to cadaveric knees.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Sena MP, DellaMaggioria R, Lotz JC, Feeley BT

Novel diagnostic and prognostic methods for disc degeneration and low back pain.

The spine journal : official journal of the North American Spine Society

Samartzis D, Borthakur A, Belfer I, Bow C, Lotz JC, Wang HQ, Cheung KM, Carragee E, Karppinen J

Spaceflight-induced bone loss alters failure mode and reduces bending strength in murine spinal segments.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Berg-Johansen B, Liebenberg EC, Li A, Macias BR, Hargens AR, Lotz JC

Cardiovascular magnetic resonance feature-tracking assessment of myocardial mechanics: Intervendor agreement and considerations regarding reproducibility.

Clinical radiology

Schuster A, Stahnke VC, Unterberg-Buchwald C, Kowallick JT, Lamata P, Steinmetz M, Kutty S, Fasshauer M, Staab W, Sohns JM, Bigalke B, Ritter C, Hasenfuß G, Beerbaum P, Lotz J

Neural innervation patterns in the sacral vertebral body.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Degmetich S, Bailey JF, Liebenberg E, Lotz JC

Osteoclast activators are elevated in intervertebral disks with Modic changes among patients operated for herniated nucleus pulposus.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Torkki M, Majuri ML, Wolff H, Koskelainen T, Haapea M, Niinimäki J, Alenius H, Lotz J, Karppinen J

Alterations in intervertebral disc composition, matrix homeostasis and biomechanical behavior in the UCD-T2DM rat model of type 2 diabetes.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Fields AJ, Berg-Johansen B, Metz LN, Miller S, La B, Liebenberg EC, Coughlin DG, Graham JL, Stanhope KL, Havel PJ, Lotz JC

Drug-induced changes to the vertebral endplate vasculature affect transport into the intervertebral disc in vivo.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Gullbrand SE, Peterson J, Mastropolo R, Lawrence JP, Lopes L, Lotz J, Ledet EH

Comparison of vertebral and intervertebral disc lesions in aging humans and rhesus monkeys.

Osteoarthritis and cartilage

Bailey JF, Fields AJ, Liebenberg E, Mattison JA, Lotz JC, Kramer PA

The anabolic effect of plasma-mediated ablation on the intervertebral disc: stimulation of proteoglycan and interleukin-8 production.

The spine journal : official journal of the North American Spine Society

Kuelling FA, Foley KT, Liu JJ, Liebenberg E, Sin AH, Matsukawa A, Lotz JC

Influence of biochemical composition on endplate cartilage tensile properties in the human lumbar spine.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Fields AJ, Rodriguez D, Gary KN, Liebenberg EC, Lotz JC

Intervertebral discs from spinal nondeformity and deformity patients have different mechanical and matrix properties.

The spine journal : official journal of the North American Spine Society

Cheng KK, Berven SH, Hu SS, Lotz JC

On representations for joint moments using a joint coordinate system.

Journal of biomechanical engineering

O'Reilly OM, Sena MP, Feeley BT, Lotz JC

Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc.

The spine journal : official journal of the North American Spine Society

Fields AJ, Liebenberg EC, Lotz JC

Disk degeneration and low back pain: are they fat-related conditions?

Global spine journal

Samartzis D, Karppinen J, Cheung JP, Lotz J

The role of the vertebral end plate in low back pain.

Global spine journal

Lotz JC, Fields AJ, Liebenberg EC

Dynamic evaluation of pivot-shift kinematics in physeal-sparing pediatric anterior cruciate ligament reconstruction techniques.

The American journal of sports medicine

Sena M, Chen J, Dellamaggioria R, Coughlin DG, Lotz JC, Feeley BT

New treatments and imaging strategies in degenerative disease of the intervertebral disks.

Radiology

Lotz JC, Haughton V, Boden SD, An HS, Kang JD, Masuda K, Freemont A, Berven S, Sengupta DK, Tanenbaum L, Maurer P, Ranganathan A, Alavi A, Marinelli NL

[Consensus recommendations of the German Radiology Society (DRG), the German Cardiac Society (DGK) and the German Society for Pediatric Cardiology (DGPK) on the use of cardiac imaging with computed tomography and magnetic resonance imaging].

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

Achenbach S, Barkhausen J, Beer M, Beerbaum P, Dill T, Eichhorn J, Fratz S, Gutberlet M, Hoffmann M, Huber A, Hunold P, Klein C, Krombach G, Kreitner KF, Kühne T, Lotz J, Maintz D, Mahrholdt H, Marholdt H, Merkle N, Messroghli D, Miller S, Paetsch I, Radke P, Steen H, Thiele H, Sarikouch S, Fischbach R

Porcine intervertebral disc repair using allogeneic juvenile articular chondrocytes or mesenchymal stem cells.

Tissue engineering. Part A

Acosta FL, Metz L, Adkisson HD, Liu J, Carruthers-Liebenberg E, Milliman C, Maloney M, Lotz JC

Biological and biomechanical effects of fibrin injection into porcine intervertebral discs.

Spine

Buser Z, Kuelling F, Liu J, Liebenberg E, Thorne KJ, Coughlin D, Lotz JC

Morphology of the human vertebral endplate.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Rodriguez AG, Rodriguez-Soto AE, Burghardt AJ, Berven S, Majumdar S, Lotz JC

Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy.

Osteoarthritis and cartilage

Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T

Human disc nucleus properties and vertebral endplate permeability.

Spine

Rodriguez AG, Slichter CK, Acosta FL, Rodriguez-Soto AE, Burghardt AJ, Majumdar S, Lotz JC

A musculoskeletal model for the lumbar spine.

Biomechanics and modeling in mechanobiology

Christophy M, Faruk Senan NA, Lotz JC, O'Reilly OM

Biomechanical evaluation of pediatric anterior cruciate ligament reconstruction techniques.

The American journal of sports medicine

Kennedy A, Coughlin DG, Metzger MF, Tang R, Pearle AD, Lotz JC, Feeley BT

Innervation patterns of PGP 9.5-positive nerve fibers within the human lumbar vertebra.

Journal of anatomy

Bailey JF, Liebenberg E, Degmetich S, Lotz JC

Load and the spine. How does the Goldilocks principle apply?

The spine journal : official journal of the North American Spine Society

Lotz JC

[An introduction to the cardiac and vascular diagnostics team].

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

Miller S, Gutberlet M, Lotz J, Fischbach R, Barkhausen J

Structured coculture of stem cells and disc cells prevent disc degeneration in a rat model.

The spine journal : official journal of the North American Spine Society

Allon AA, Aurouer N, Yoo BB, Liebenberg EC, Buser Z, Lotz JC

Minimizing errors associated with calculating the location of the helical axis for spinal motions.

Journal of biomechanics

Metzger MF, Faruk Senan NA, O'Reilly OM, Lotz JC

Antithrombogenic modification of small-diameter microfibrous vascular grafts.

Arteriosclerosis, thrombosis, and vascular biology

Hashi CK, Derugin N, Janairo RR, Lee R, Schultz D, Lotz J, Li S

Pure moment testing for spinal biomechanics applications: Fixed versus sliding ring cable-driven test designs.

Journal of biomechanics

Eguizabal J, Tufaga M, Scheer JK, Ames C, Lotz JC, Buckley JM

New challenges for intervertebral disc treatment using regenerative medicine.

Tissue engineering. Part B, Reviews

Masuda K, Lotz JC

Trials of vertebroplasty for vertebral fractures.

The New England journal of medicine

Lotz JC

On the stiffness matrix of the intervertebral joint: application to total disk replacement.

Journal of biomechanical engineering

O'Reilly OM, Metzger MF, Buckley JM, Moody DA, Lotz JC

[Recommendations for utilizing computerized tomography and magnetic resonance tomography in heart diagnosis. 2--Magnetic resonance tomography ].

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

Lotz J, Kivelitz D, Fischbach R, Beer M, Miller S

The influence of ferucarbotran on the chondrogenesis of human mesenchymal stem cells.

Contrast media & molecular imaging

Henning TD, Sutton EJ, Kim A, Golovko D, Horvai A, Ackerman L, Sennino B, McDonald D, Lotz J, Daldrup-Link HE

The tissue diagnostic instrument.

The Review of scientific instruments

Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Diez-Perez A, Alliston T, Weaver V, Lotz J

Mechanical profiling of intervertebral discs.

Journal of biomechanics

Schultz DS, Rodriguez AG, Hansma PK, Lotz JC

Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells.

Stem cells and development

Xu J, Wang W, Kapila Y, Lotz J, Kapila S

Pressure and distortion regulate human mesenchymal stem cell gene expression.

Annals of biomedical engineering

Haudenschild AK, Hsieh AH, Kapila S, Lotz JC

Biomechanical pullout strength and stability of the cervical artificial pedicle screw.

Spine

Barnes AH, Eguizabal JA, Acosta FL, Lotz JC, Buckley JM, Ames CP

Quantifying the contributions of structure to the annulus fibrosus mechanical function using a nonlinear, anisotropic, hyperelastic model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Wagner DR, Lotz JC

Detection of postoperative granulation tissue with an ICG-enhanced integrated OI-/X-ray System.

Journal of translational medicine

Meier R, Boddington S, Krug C, Acosta FL, Thullier D, Henning TD, Sutton EJ, Tavri S, Lotz JC, Daldrup-Link HE

Anulus fibrosus tension inhibits degenerative structural changes in lamellar collagen.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Lotz JC, Hadi T, Bratton C, Reiser KM, Hsieh AH

Structural factors that mediate scleral stiffness.

Investigative ophthalmology & visual science

Schultz DS, Lotz JC, Lee SM, Trinidad ML, Stewart JM

Chondrogenic differentiation of human mesenchymal stem cells in three-dimensional alginate gels.

Tissue engineering. Part A

Xu J, Wang W, Ludeman M, Cheng K, Hayami T, Lotz JC, Kapila S

Lactic acid and proteoglycans as metabolic markers for discogenic back pain.

Spine

Keshari KR, Lotz JC, Link TM, Hu S, Majumdar S, Kurhanewicz J

ISSLS prize winner: repeated disc injury causes persistent inflammation.

Spine

Ulrich JA, Liebenberg EC, Thuillier DU, Lotz JC

Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration.

PloS one

Behonick DJ, Xing Z, Lieu S, Buckley JM, Lotz JC, Marcucio RS, Werb Z, Miclau T, Colnot C

Quantitative analysis of structural disorder in intervertebral disks using second harmonic generation imaging: comparison with morphometric analysis.

Journal of biomedical optics

Reiser KM, Bratton C, Yankelevich DR, Knoesen A, Rocha-Mendoza I, Lotz J

Biological and mechanical consequences of transient intervertebral disc bending.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Court C, Chin JR, Liebenberg E, Colliou OK, Lotz JC

Relationship between femoral head size and distance to lesser trochanter.

Clinical orthopaedics and related research

Sproul RC, Reynolds HM, Lotz JC, Ries MD

In vitro system for applying cyclic loads to connective tissues under displacement or force control.

Annals of biomedical engineering

Asundi KR, Kursa K, Lotz J, Rempel DM

Intradiscal thermal therapy using interstitial ultrasound: an in vivo investigation in ovine cervical spine.

Spine

Nau WH, Diederich CJ, Shu R, Kinsey A, Bass E, Lotz J, Hu S, Simko J, Ferrier W, Sutton J, Attawia M, Pellegrino R

The short-term effects of electrosurgical ablation on proinflammatory mediator production by intervertebral disc cells in tissue culture.

The spine journal : official journal of the North American Spine Society

Rhyu KW, Walsh AJ, O'Neill CW, Bradford DS, Lotz JC

Glucosamine HCl alters production of inflammatory mediators by rat intervertebral disc cells in vitro.

The spine journal : official journal of the North American Spine Society

Walsh AJ, O'neill CW, Lotz JC

Stab incision for inducing intervertebral disc degeneration in the rat.

Spine

Rousseau MA, Ulrich JA, Bass EC, Rodriguez AG, Liu JJ, Lotz JC

Intradiscal thermal therapy does not stimulate biologic remodeling in an in vivo sheep model.

Spine

Bass EC, Nau WH, Diederich CJ, Liebenberg E, Shu R, Pellegrino R, Sutton J, Attawia M, Hu SS, Ferrier WT, Lotz JC

Disc regeneration: why, when, and how.

Neurosurgery clinics of North America

Lotz JC, Kim AJ

Basic fibroblast growth factor improves trabecular bone connectivity and bone strength in the lumbar vertebral body of osteopenic rats.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Yao W, Hadi T, Jiang Y, Lotz J, Wronski TJ, Lane NE

Characterization of intervertebral disc degeneration by high-resolution magic angle spinning (HR-MAS) spectroscopy.

Magnetic resonance in medicine

Keshari KR, Zektzer AS, Swanson MG, Majumdar S, Lotz JC, Kurhanewicz J

Effects of controlled dynamic disc distraction on degenerated intervertebral discs: an in vivo study on the rabbit lumbar spine model.

Spine

Kroeber M, Unglaub F, Guehring T, Guegring T, Nerlich A, Hadi T, Lotz J, Carstens C

Carpal tunnel pressure alters median nerve function in a dose-dependent manner: a rabbit model for carpal tunnel syndrome.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Diao E, Shao F, Liebenberg E, Rempel D, Lotz JC

The effect on anterior column loading due to different vertebral augmentation techniques.

Clinical biomechanics (Bristol, Avon)

Ananthakrishnan D, Berven S, Deviren V, Cheng K, Lotz JC, Xu Z, Puttlitz CM

Intervertebral disc replacement maintains cervical spine kinetics.

Spine

Puttlitz CM, Rousseau MA, Xu Z, Hu S, Tay BK, Lotz JC

Introduction: disc degeneration: summary.

Spine

An HS, Anderson PA, Haughton VM, Iatridis JC, Kang JD, Lotz JC, Natarajan RN, Oegema TR, Roughley P, Setton LA, Urban JP, Videman T, Andersson GB, Weinstein JN

A phase IIA study of the topoisomerase I inhibitor, exatecan mesylate (DX-8951f), administered at two different dose schedules in patients with platinum- and taxane-resistant/refractory ovarian cancer.

Gynecologic oncology

Clamp A, Adams M, Atkinson R, Boven E, Calvert AH, Cervantes A, Ganesan T, Lotz J, Vasey P, Cheverton P, Jayson GC

Biaxial testing of human annulus fibrosus and its implications for a constitutive formulation.

Annals of biomedical engineering

Bass EC, Ashford FA, Segal MR, Lotz JC

Diffraction enhanced imaging of articular cartilage and comparison with micro-computed tomography of the underlying bone structure.

European radiology

Majumdar S, Issever AS, Burghardt A, Lotz J, Arfelli F, Rigon L, Heitner G, Menk RH

Theoretical model and experimental results for the nonlinear elastic behavior of human annulus fibrosus.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Wagner DR, Lotz JC

Ventral approach to the lumbar spine of the Sprague-Dawley rat.

Lab animal

Rousseau MA, Bass EC, Lotz JC

Biomechanics of cervical laminoplasty: kinetic studies comparing different surgical techniques, temporal effects and the degree of level involvement.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Puttlitz CM, Deviren V, Smith JA, Kleinstueck FS, Tran QN, Thurlow RW, Eisele P, Lotz JC

A three-dimensional MRI analysis of knee kinematics.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Patel VV, Hall K, Ries M, Lotz J, Ozhinsky E, Lindsey C, Lu Y, Majumdar S

Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs.

Annals of biomedical engineering

Crevensten G, Walsh AJ, Ananthakrishnan D, Page P, Wahba GM, Lotz JC, Berven S

Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload.

The American journal of pathology

Rannou F, Lee TS, Zhou RH, Chin J, Lotz JC, Mayoux-Benhamou MA, Barbet JP, Chevrot A, Shyy JY

Stability analysis of craniovertebral junction fixation techniques.

The Journal of bone and joint surgery. American volume

Puttlitz CM, Melcher RP, Kleinstueck FS, Harms J, Bradford DS, Lotz JC

Heat-induced changes in porcine annulus fibrosus biomechanics.

Journal of biomechanics

Bass EC, Wistrom EV, Diederich CJ, Nau WH, Pellegrino R, Ruberti J, Lotz JC

Mechanobiology in intervertebral disc degeneration and regeneration.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Lotz JC, Staples A, Walsh A, Hsieh AH

Percutaneous plasma decompression alters cytokine expression in injured porcine intervertebral discs.

The spine journal : official journal of the North American Spine Society

O'Neill CW, Liu JJ, Leibenberg E, Hu SS, Deviren V, Tay BK, Chin CT, Lotz JC

Polarization-modulated second harmonic generation imaging: method for quantitative assessment of disorganization in anulus.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Reiser KM, Rocha-Mendoza I, Wang M, Yankelevich DR, Bratton C, Knoesen A, Lotz JC, Liebenman E

The compressive creep properties of normal and degenerated murine intervertebral discs.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Palmer EI, Lotz JC

Temperature and thermal dose distributions during intradiscal electrothermal therapy in the cadaveric lumbar spine.

Spine

Kleinstueck FS, Diederich CJ, Nau WH, Puttlitz CM, Smith JA, Bradford DS, Lotz JC

Dorsal and palmar material properties of the adult human flexor profundus tendon in Zone II.

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand

Soejima O, Diao E, Lotz JC, Hariharan JS, Naito M

Effect of cementless bowed stem distal surface contour and coronal slot on femoral bone strains and torsional stability.

The Journal of arthroplasty

Ries MD, Suzuki Y, Renowitzky G, Lotz JC, Barrack RL, Bourne RB, Rorabeck CH

Scaphoid kinematic behavior after division of the transverse carpal ligament.

The Journal of hand surgery

Ishiko T, Puttlitz CM, Lotz JC, Diao E

Micro-computed tomography evaluation of trabecular bone structure on loaded mice tail vertebrae.

Spine

Issever AS, Walsh A, Lu Y, Burghardt A, Lotz JC, Majumdar S

Biomechanical testing of posterior atlantoaxial fixation techniques.

Spine

Melcher RP, Puttlitz CM, Kleinstueck FS, Lotz JC, Harms J, Bradford DS

Mechanobiology of the intervertebral disc.

Biochemical Society transactions

Lotz JC, Hsieh AH, Walsh AL, Palmer EI, Chin JR

The effects of synthetic conjugated estrogens, a (cenestin) on trabecular bone structure and strength in the ovariectomized rat model.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Lane NE, Kumer JL, Majumdar S, Khan M, Lotz J, Stevens RE, Klein R, Phelps KV

The internal mechanics of the intervertebral disc under cyclic loading.

Journal of biomechanics

Riches PE, Dhillon N, Lotz J, Woods AW, McNally DS

Impact biomechanics and pelvic deformation during insertion of press-fit acetabular cups.

The Journal of arthroplasty

Kroeber M, Ries MD, Suzuki Y, Renowitzky G, Ashford F, Lotz J

Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition.

Nature genetics

Mao JR, Taylor G, Dean WB, Wagner DR, Afzal V, Lotz JC, Rubin EM, Bristow J

Acute biomechanical and histological effects of intradiscal electrothermal therapy on human lumbar discs.

Spine

Kleinstueck FS, Diederich CJ, Nau WH, Puttlitz CM, Smith JA, Bradford DS, Lotz JC

Parametric finite element analysis of vertebral bodies affected by tumors.

Journal of biomechanics

Whyne CM, Hu SS, Lotz JC

Postoperative reduction of fibrinolysis as a prognostic factor of fatal outcome.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Lotz J, Walgenbach S, Peetz D, Dutkowski P, Junginger T, Prellwitz W, Hafner G

The effect of static in vivo bending on the murine intervertebral disc.

The spine journal : official journal of the North American Spine Society

Court C, Colliou OK, Chin JR, Liebenberg E, Bradford DS, Lotz JC

Biphasic material properties of lytic bone metastases.

Annals of biomedical engineering

Whyne CM, Hu SS, Workman KL, Lotz JC

Anisotropic shear behavior of the annulus fibrosus: effect of harvest site and tissue prestrain.

Medical engineering & physics

Fujita Y, Wagner DR, Biviji AA, Duncan NA, Lotz JC

Tibial plateau fracture as a measure of early estrogen-dependent bone fragility in rats.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lotz JC, Kroeber MW, Heilmann M, Pericherla K, Kimmel D, Kinney JH, Lane NE

Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass.

Development (Cambridge, England)

Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R

Randomized biomechanical study of zone II human flexor tendon repairs.

The Journal of hand surgery

Diao E, Soejima O, Lotz J, Hariharan J

Collagen type I metabolism after bone surgery.

Archives of orthopaedic and trauma surgery

Lotz J, Gaertner T, Hahn M, Prellwitz W

Use of a collagen-hydroxyapatite matrix in spinal fusion. A rabbit model.

Spine

Tay BK, Le AX, Heilman M, Lotz J, Bradford DS

Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice.

The American journal of pathology

Schirmacher P, Peters M, Ciliberto G, Blessing M, Lotz J, Meyer zum Büschenfelde KH, Rose-John S

Analytic model to predict the strength of tendon repairs.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lotz JC, Hariharan JS, Diao E

[Follow-up of collagen and bone metabolism in patients with cement-free total hip endoprosthesis].

Zeitschrift fur Orthopadie und ihre Grenzgebiete

Meurer A, Lotz J, Giesa M, Eckardt A, Prellwitz W, Heine J

Use of ultrasound in spinal arthrodesis. A rabbit model.

Spine

Glazer PA, Heilmann MR, Lotz JC, Bradford DS

Effect of long-term treatment with GH on bone metabolism, bone mineral density and bone elasticity in GH-deficient adults.

Clinical endocrinology

Kann P, Piepkorn B, Schehler B, Andreas J, Lotz J, Prellwitz W, Beyer J

Frozen storage affects the compressive creep behavior of the porcine intervertebral disc.

Spine

Bass EC, Duncan NA, Hariharan JS, Dusick J, Bueff HU, Lotz JC

Carbonated apatite cement augmentation of pedicle screw fixation in the lumbar spine.

Spine

Lotz JC, Hu SS, Chiu DF, Yu M, Colliou O, Poser RD

Partial lacerations of human digital flexor tendons: a biomechanical analysis.

The Journal of hand surgery

Hariharan JS, Diao E, Soejima O, Lotz JC

Radial tensile properties of the lumbar annulus fibrosus are site and degeneration dependent.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Fujita Y, Duncan NA, Lotz JC

Use of electromagnetic fields in a spinal fusion. A rabbit model.

Spine

Glazer PA, Heilmann MR, Lotz JC, Bradford DS

Biomechanical analysis of multilevel fixation methods in the lumbar spine.

Spine

Glazer PA, Colliou O, Klisch SM, Bradfore DS, Bueff HU, Lotz JC

Biomechanical analysis of lumbosacral fixation.

Spine

Glazer PA, Colliou O, Lotz JC, Bradford DS

Effect of peripheral suture depth on strength of tendon repairs.

The Journal of hand surgery

Diao E, Hariharan JS, Soejima O, Lotz JC

Magnetic resonance imaging of trabecular bone structure in the distal radius: relationship with X-ray tomographic microscopy and biomechanics.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Majumdar S, Newitt D, Mathur A, Osman D, Gies A, Chiu E, Lotz J, Kinney J, Genant H

Instrumentation of the cervicothoracic junction after destabilization.

Spine

Bueff HU, Lotz JC, Colliou OK, Khapchik V, Ashford F, Hu SS, Bozic K, Bradford DS

Evaluation of an automated chromogenic substrate assay for the rapid determination of hirudin in plasma.

Thrombosis research

Hafner G, Fickenscher K, Friesen HJ, Rupprecht HJ, Konheiser U, Ehrenthal W, Lotz J, Prellwitz W

Stress distributions within the proximal femur during gait and falls: implications for osteoporotic fracture.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Lotz JC, Cheal EJ, Hayes WC

Fracture prediction for the proximal femur using finite element models: Part I--Linear analysis.

Journal of biomechanical engineering

Lotz JC, Cheal EJ, Hayes WC

Mechanical properties of metaphyseal bone in the proximal femur.

Journal of biomechanics

Lotz JC, Gerhart TN, Hayes WC

The use of quantitative computed tomography to estimate risk of fracture of the hip from falls.

The Journal of bone and joint surgery. American volume

Lotz JC, Hayes WC

Biomechanical properties of the proximal femur determined in vitro by single-energy quantitative computed tomography.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Esses SI, Lotz JC, Hayes WC