Kelsey Collins, PhD | Health Innovation via Engineering

Assistant Professor In Res

Orthopaedic Surgery

In the Laboratory for Musculoskeletal Crosstalk, we leverage interdisciplinary approaches in bioengineering, endocrinology, and physiology to determine molecular mechanisms of tissue crosstalk in osteoarthritis. Our work aims to delineate fat-cartilage signals that contribute to osteoarthritis susceptibility and pain to generate a new class of regenerative medicine-based therapies. We use in vitro and in vivo approaches, induced pluripotent stem cells, CRISPR-Cas9 genome engineering, mouse models, human tissues, and state-of-the-art multi-omic spatial approaches. As pathological fat signaling may play a role in many disease processes, we work to define the mechanisms and create therapies that have implications to aging, obesity, diabetes and other chronic diseases.

Publications

Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice.

Arthritis research & therapy

Ely EV, Lenz KL, Paradi SG, Ack S, Behrmann A, Dunivan S, Braxton L, Liedtke W, Chen Y, Collins KH, Guilak F

Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury.

Research square

Tjandra P, Andoko B, Kim J, Gomez A, Sar S, Aepala M, Pham T, Dumlao D, Welhaven H, Collins K

Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury.

bioRxiv : the preprint server for biology

Tjandra PM, Andoko BA, Kim JA, Gomez AG, Sar S, Aepala MR, Pham TTK, Dumlao D, Welhaven HD, Collins KH

Chondrocyte-Specific Knockout of Piezo1 and Piezo2 Protects Against Post-Traumatic Osteoarthritis Structural Damage and Pain in Mice.

bioRxiv : the preprint server for biology

Ely EV, Lenz KL, Paradi SG, Ack S, Behrmann A, Dunivan S, Braxton L, Liedtke W, Chen Y, Collins KH, Guilak F

Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain.

Science advances

Collins KH, Lenz KL, Welhaven HD, Ely E, Springer LE, Paradi S, Tang R, Braxton L, Akk A, Yan H, Zhang B, Wu X, Atkinson JP, Oestreich AK, June RK, Pham CTN, Guilak F

Engineered self-regulating macrophages for targeted anti-inflammatory drug delivery.

Arthritis research & therapy

Klimak M, Cimino A, Lenz KL, Springer LE, Collins KH, Harasymowicz NS, Xu N, Pham CTN, Guilak F

Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People with Metabolically Abnormal Obesity.

Diabetes

Shen KC, Collins KH, Ferey JLA, Fappi A, McCormick JJ, Mittendorfer B, Guilak F, Meyer GA

Independent and combined effects of obesity and traumatic joint injury to the structure and composition of rat knee cartilage.

Connective tissue research

Karjalainen K, Tanska P, Collins KH, Herzog W, Korhonen RK, Moo EK

Evolution and advancements in genomics and epigenomics in OA research: How far we have come.

Osteoarthritis and cartilage

Ramos Y, Rice SJ, Ali SA, Pastrello C, Jurisica I, Rai MF, Collins KH, Lang A, Maerz T, Geurts J, Ruiz-Romero C, June RK, Thomas Appleton C, Rockel JS, Kapoor M

Three Decades of Advancements in Osteoarthritis Research: Insights from Transcriptomic, Proteomic, and Metabolomic Studies.

Osteoarthritis and cartilage

Rai MF, Collins KH, Lang A, Maerz T, Geurts J, Ruiz-Romero C, June RK, Ramos Y, Rice SJ, Ali SA, Pastrello C, Jurisica I, Thomas Appleton C, Rockel JS, Kapoor M

Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat-High-Sucrose Diet in a Rat Model.

Cartilage

Abughazaleh N, Boldt K, Rios JL, Mattiello SM, Collins KH, Seerattan RA, Herzog W

Post or Perish? Social Media Strategies for Disseminating Orthopedic Research.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Buettmann EG, Chlebek C, Lockard CA, Clayton SW, Lewis KJ, Collins KH

Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy.

Gels (Basel, Switzerland)

Collins KH, Pferdehirt L, Saleh LS, Savadipour A, Springer LE, Lenz KL, Thompson DM, Oswald SJ, Pham CTN, Guilak F

The role of PIEZO ion channels in the musculoskeletal system.

American journal of physiology. Cell physiology

Savadipour A, Palmer D, Ely EV, Collins KH, Garcia-Castorena JM, Harissa Z, Kim YS, Oestrich A, Qu F, Rashidi N, Guilak F

#OrthoTwitter: Relationship Between Author Twitter Utilization and Academic Impact in Orthopaedic Surgery.

Cureus

Halvorson RT, Allahabadi S, Cevallos N, Foley AJ, Collins K, Torres Espin A, Feeley BT, Pandya NK, Bailey JF

Trimming the fat - is leptin crosstalk the link between obesity and osteoarthritis?

Osteoarthritis and cartilage

Collins KH, Guilak F

Leptin mediates the regulation of muscle mass and strength by adipose tissue.

The Journal of physiology

Collins KH, Gui C, Ely EV, Lenz KL, Harris CA, Guilak F, Meyer GA

A genome-engineered bioartificial implant for autoregulated anticytokine drug delivery.

Science advances

Choi YR, Collins KH, Springer LE, Pferdehirt L, Ross AK, Wu CL, Moutos FT, Harasymowicz NS, Brunger JM, Pham CTN, Guilak F

Taxonomic changes in the gut microbiota are associated with cartilage damage independent of adiposity, high fat diet, and joint injury.

Scientific reports

Collins KH, Schwartz DJ, Lenz KL, Harris CA, Guilak F

Contractility of permeabilized rat vastus intermedius muscle fibres following high-fat, high-sucrose diet consumption.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

Smith IC, Ostertag C, O'Reilly JJ, Rios JL, Klancic T, MacDonald GZ, Collins KH, Reimer RA, Herzog W

Immunoengineering the next generation of arthritis therapies.

Acta biomaterialia

Klimak M, Nims RJ, Pferdehirt L, Collins KH, Harasymowicz NS, Oswald SJ, Setton LA, Guilak F

Adipose tissue is a critical regulator of osteoarthritis.

Proceedings of the National Academy of Sciences of the United States of America

Collins KH, Lenz KL, Pollitt EN, Ferguson D, Hutson I, Springer LE, Oestreich AK, Tang R, Choi YR, Meyer GA, Teitelbaum SL, Pham CTN, Harris CA, Guilak F

Is Obesity a Disease of Stem Cells?

Cell stem cell

Oestreich AK, Collins KH, Harasymowicz NS, Wu CL, Guilak F

Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction.

The Journal of physiology

Biltz NK, Collins KH, Shen KC, Schwartz K, Harris CA, Meyer GA

Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity.

Science advances

Tang R, Harasymowicz NS, Wu CL, Collins KH, Choi YR, Oswald SJ, Guilak F

The role of macrophages in osteoarthritis and cartilage repair.

Osteoarthritis and cartilage

Wu CL, Harasymowicz NS, Klimak MA, Collins KH, Guilak F

Impact of age on host responses to diet-induced obesity: Development of joint damage and metabolic set points.

Journal of sport and health science

Collins KH, MacDonald GZ, Hart DA, Seerattan RA, Rios JL, Reimer RA, Herzog W

Designer Stem Cells: Genome Engineering and the Next Generation of Cell-Based Therapies.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Guilak F, Pferdehirt L, Ross AK, Choi YR, Collins K, Nims RJ, Katz DB, Klimak M, Tabbaa S, Pham CTN

Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity.

Scientific reports

Rios JL, Bomhof MR, Reimer RA, Hart DA, Collins KH, Herzog W

Nanotherapy Targeting NF-?B Attenuates Acute Pain After Joint Injury.

Precision nanomedicine

Yan H, Duan X, Collins KH, Springer LE, Guilak F, Wickline SA, Rai MF, Pan H, Pham CTN

Maternal prebiotic supplementation reduces fatty liver development in offspring through altered microbial and metabolomic profiles in rats.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Paul HA, Collins KH, Nicolucci AC, Urbanski SJ, Hart DA, Vogel HJ, Reimer RA

Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs.

Tissue engineering and regenerative medicine

Choi YR, Collins KH, Lee JW, Kang HJ, Guilak F

Association of Metabolic Markers with self-reported osteoarthritis among middle-aged BMI-defined non-obese individuals: a cross-sectional study.

BMC obesity

Collins KH, Sharif B, Reimer RA, Sanmartin C, Herzog W, Chin R, Marshall DA

High-fat/high-sucrose diet-induced obesity results in joint-specific development of osteoarthritis-like degeneration in a rat model.

Bone & joint research

Collins KH, Hart DA, Seerattan RA, Reimer RA, Herzog W

Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity.

Frontiers in physiology

Collins KH, Herzog W, MacDonald GZ, Reimer RA, Rios JL, Smith IC, Zernicke RF, Hart DA

Potential Impact of Metabolic and Gut Microbial Response to Pregnancy and Lactation in Lean and Diet-Induced Obese Rats on Offspring Obesity Risk.

Molecular nutrition & food research

Paul HA, Collins KH, Bomhof MR, Vogel HJ, Reimer RA

Diet-induced obesity leads to pro-inflammatory alterations to the vitreous humour of the eye in a rat model.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Collins KH, Herzog W, Reimer RA, Reno CR, Heard BJ, Hart DA

Acute and chronic changes in rat soleus muscle after high-fat high-sucrose diet.

Physiological reports

Collins KH, Hart DA, Smith IC, Issler AM, Reimer RA, Seerattan RA, Rios JL, Herzog W

Association of body mass index (BMI) and percent body fat among BMI-defined non-obese middle-aged individuals: Insights from a population-based Canadian sample.

Canadian journal of public health = Revue canadienne de sante publique

Collins KH, Sharif B, Sanmartin C, Reimer RA, Herzog W, Chin R, Marshall DA

A High-Fat High-Sucrose Diet Rapidly Alters Muscle Integrity, Inflammation and Gut Microbiota in Male Rats.

Scientific reports

Collins KH, Paul HA, Hart DA, Reimer RA, Smith IC, Rios JL, Seerattan RA, Herzog W

Reduced knee adduction moments for management of knee osteoarthritis:: A three month phase I/II randomized controlled trial.

Gait & posture

Lewinson RT, Vallerand IA, Collins KH, Wiley JP, Lun VMY, Patel C, Woodhouse LJ, Reimer RA, Worobets JT, Herzog W, Stefanyshyn DJ

High-fat high-sucrose diet leads to dynamic structural and inflammatory alterations in the rat vastus lateralis muscle.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Collins KH, Hart DA, Reimer RA, Seerattan RA, Waters-Banker C, Sibole SC, Herzog W

Response to diet-induced obesity produces time-dependent induction and progression of metabolic osteoarthritis in rat knees.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Collins KH, Hart DA, Reimer RA, Seerattan RA, Herzog W

Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model.

Osteoarthritis and cartilage

Collins KH, Paul HA, Reimer RA, Seerattan RA, Hart DA, Herzog W

Using diet-induced obesity to understand a metabolic subtype of osteoarthritis in rats.

Osteoarthritis and cartilage

Collins KH, Reimer RA, Seerattan RA, Leonard TR, Herzog W

Reduced knee joint loading with lateral and medial wedge insoles for management of knee osteoarthritis: a protocol for a randomized controlled trial.

BMC musculoskeletal disorders

Lewinson RT, Collins KH, Vallerand IA, Wiley JP, Woodhouse LJ, Reimer RA, Worobets JT, Herzog W, Stefanyshyn DJ

Ground reaction force estimates from ActiGraph GT3X+ hip accelerations.

PloS one

Neugebauer JM, Collins KH, Hawkins DA

Publications

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