Ritchie Chen, PhD, MSc, BS

Asst Professor In Residence
Neurological Surgery

We engineer technologies to study brain-body physiology and to inform new therapeutic approaches for bioelectronic medicine. We fuse approaches in synthetic biology, nanotechnology, device engineering, and systems neuroscience to develop genetically-targeted tools to target, map, readout, and/or control neural circuits while minimizing damage to tissue.


Cardiogenic control of affective behavioural state.


Hsueh B, Chen R, Jo Y, Tang D, Raffiee M, Kim YS, Inoue M, Randles S, Ramakrishnan C, Patel S, Kim DK, Liu TX, Kim SH, Tan L, Mortazavi L, Cordero A, Shi J, Zhao M, Ho TT, Crow A, Yoo AW, Raja C, Evans K, Bernstein D, Zeineh M, Goubran M, Deisseroth K

Cell-type-specific population dynamics of diverse reward computations.


Sylwestrak EL, Jo Y, Vesuna S, Wang X, Holcomb B, Tien RH, Kim DK, Fenno L, Ramakrishnan C, Allen WE, Chen R, Shenoy KV, Sussillo D, Deisseroth K

Deep brain optogenetics without intracranial surgery.

Nature biotechnology

Chen R, Gore F, Nguyen QA, Ramakrishnan C, Patel S, Kim SH, Raffiee M, Kim YS, Hsueh B, Krook-Magnusson E, Soltesz I, Deisseroth K

Multiple convergent hypothalamus-brainstem circuits drive defensive behavior.

Nature neuroscience

Lovett-Barron M, Chen R, Bradbury S, Andalman AS, Wagle M, Guo S, Deisseroth K

Stretchable and Fully Degradable Semiconductors for Transient Electronics.

ACS central science

Tran H, Feig VR, Liu K, Wu HC, Chen R, Xu J, Deisseroth K, Bao Z

Remotely controlled chemomagnetic modulation of targeted neural circuits.

Nature nanotechnology

Rao S, Chen R, LaRocca AA, Christiansen MG, Senko AW, Shi CH, Chiang PH, Varnavides G, Xue J, Zhou Y, Park S, Ding R, Moon J, Feng G, Anikeeva P

Neuronal Dynamics Regulating Brain and Behavioral State Transitions.


Andalman AS, Burns VM, Lovett-Barron M, Broxton M, Poole B, Yang SJ, Grosenick L, Lerner TN, Chen R, Benster T, Mourrain P, Levoy M, Rajan K, Deisseroth K

Protection of tissue physicochemical properties using polyfunctional crosslinkers.

Nature biotechnology

Park YG, Sohn CH, Chen R, McCue M, Yun DH, Drummond GT, Ku T, Evans NB, Oak HC, Trieu W, Choi H, Jin X, Lilascharoen V, Wang J, Truttmann MC, Qi HW, Ploegh HL, Golub TR, Chen SC, Frosch MP, Kulik HJ, Lim BK, Chung K

One-step optogenetics with multifunctional flexible polymer fibers.

Nature neuroscience

Park S, Guo Y, Jia X, Choe HK, Grena B, Kang J, Park J, Lu C, Canales A, Chen R, Yim YS, Choi GB, Fink Y, Anikeeva P

Neural Recording and Modulation Technologies.

Nature reviews. Materials

Chen R, Canales A, Anikeeva P

High-Performance Ferrite Nanoparticles through Nonaqueous Redox Phase Tuning.

Nano letters

Chen R, Christiansen MG, Sourakov A, Mohr A, Matsumoto Y, Okada S, Jasanoff A, Anikeeva P

Engineering intracellular biomineralization and biosensing by a magnetic protein.

Nature communications

Matsumoto Y, Chen R, Anikeeva P, Jasanoff A

Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-� Aggregates.

Advanced healthcare materials

Loynachan CN, Romero G, Christiansen MG, Chen R, Ellison R, O'Malley TT, Froriep UP, Walsh DM, Anikeeva P

Wireless magnetothermal deep brain stimulation.

Science (New York, N.Y.)

Chen R, Romero G, Christiansen MG, Mohr A, Anikeeva P

Folding of a single-chain, information-rich polypeptoid sequence into a highly ordered nanosheet.


Kudirka R, Tran H, Sanii B, Nam KT, Choi PH, Venkateswaran N, Chen R, Whitelam S, Zuckermann RN

Free-floating ultrathin two-dimensional crystals from sequence-specific peptoid polymers.

Nature materials

Nam KT, Shelby SA, Choi PH, Marciel AB, Chen R, Tan L, Chu TK, Mesch RA, Lee BC, Connolly MD, Kisielowski C, Zuckermann RN