Valerie Weaver, PhD

Professor
Surgery
+1 415 476-3826

Dr. Weaver is a professor in the Department of Surgery and the director of the Center for Bioengineering and Tissue Regeneration. Her research focuses on the contribution of force, cell-intrinsic as well as extracellular matrix, to oncogenesis and tumor development. Dr. Weaver and her lab employ 2- and 3-D in-vitro cell culture techniques, clinical samples and animal models with force application techniques, traction force and atomic force microscopy to assess the influence of the mechanical aspects of the cell environment on cell behavior and tumor progression.

Dr. Weaver earned her Bachelor of Science degree in Biochemistry/Chemistry at the University of Waterloo in 1985, and added an Honors Bachelor of Science in Biochemistry, summa cum laude, from the University of Ottawa. She earned her doctorate degree in Biochemistry from the University of Ottawa in 1992.

Publications: 

Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Nature medicine

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM

Retraction Note: Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.

Oncogene

Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth.

Cancer cell

Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF

Author Correction: Stiff matrix induces exosome secretion to promote tumour growth.

Nature cell biology

Wu B, Liu DA, Guan L, Myint PK, Chin L, Dang H, Xu Y, Ren J, Li T, Yu Z, Jabban S, Mills GB, Nukpezah J, Chen YH, Furth EE, Gimotty PA, Wells RG, Weaver VM, Radhakrishnan R, Wang XW, Guo W

Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk.

Cell stem cell

Northey JJ, Hayward MK, Yui Y, Stashko C, Kai F, Mouw JK, Thakar D, Lakins JN, Ironside AJ, Samson S, Mukhtar RA, Hwang ES, Weaver VM

The microenvironment dictates glycocalyx construction and immune surveillance.

Research square

Tharp K, Park S, Timblin G, Richards A, Twells N, Riley N, Peltan E, Shon J, Stevenson E, Tsui K, Palomba F, Lefebvre A, Soens R, Ayad N, Hoeve-Scott JT, Healy K, Digman M, Dillin A, Bertozzi C, Swaney D, Mahal L, Cantor J, Paszek M, Weaver VM, Twells N

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins.

Nature biotechnology

Pedram K, Shon DJ, Tender GS, Mantuano NR, Northey JJ, Metcalf KJ, Wisnovsky SP, Riley NM, Forcina GC, Malaker SA, Kuo A, George BM, Miller CL, Casey KM, Vilches-Moure JG, Ferracane MJ, Weaver VM, Läubli H, Bertozzi CR

Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.

bioRxiv : the preprint server for biology

Ayad NME, Lakins JN, Ghagre A, Ehrlicher AJ, Weaver VM

Correction: Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells.

The Journal of experimental medicine

Chan TS, Hsu CC, Pai VC, Liao WY, Huang SS, Tan KT, Yen CJ, Hsu SC, Chen WY, Shan YS, Li CR, Lee MT, Jiang KY, Chu JM, Lien GS, Weaver VM, Tsai KK

A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.

Nature communications

Stashko C, Hayward MK, Northey JJ, Pearson N, Ironside AJ, Lakins JN, Oria R, Goyette MA, Mayo L, Russnes HG, Hwang ES, Kutys ML, Polyak K, Weaver VM

Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.

Cell reports

Kersten K, You R, Liang S, Tharp KM, Pollack J, Weaver VM, Krummel MF, Headley MB

Author Correction: Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression.

Nature cell biology

Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM

Correction: Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.

Cancer research

Salvador F, Martin A, L?pez-Men?ndez C, Moreno-Bueno G, Santos V, V?zquez-Naharro A, Santamar?a PG, Morales S, Dubus PR, Muinelo-Romay L, L?pez-L?pez R, Tung JC, Weaver VM, Portillo F, Cano A

Stiff matrix induces exosome secretion to promote tumour growth.

Nature cell biology

Wu B, Liu DA, Guan L, Myint PK, Chin L, Dang H, Xu Y, Ren J, Li T, Yu Z, Jabban S, Mills GB, Nukpezah J, Chen YH, Furth EE, Gimotty PA, Wells RG, Weaver VM, Radhakrishnan R, Wang XW, Guo W

Programming the Self-Organization of Endothelial Cells into Perfusable Microvasculature.

Tissue engineering. Part A

Cabral KA, Srivastava V, Graham AJ, Coyle MC, Stashko C, Weaver V, Gartner Z

Extracellular Matrix Glycation and Crosslinking in Mammary Tumor Progression.

Methods in molecular biology (Clifton, N.J.)

Northey JJ, Weaver VM

Novel cryo-tomography workflow reveals nanometer-scale responses of epithelial cells to matrix stiffness and dimensionality.

Molecular biology of the cell

Gaietta G, Kai F, Swift MF, Weaver VM, Volkmann N, Hanein D

Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer.

Oncogene

Bell ES, Shah P, Zuela-Sopilniak N, Kim D, Varlet AA, Morival JLP, McGregor AL, Isermann P, Davidson PM, Elacqua JJ, Lakins JN, Vahdat L, Weaver VM, Smolka MB, Span PN, Lammerding J

ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.

The EMBO journal

Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R, Weaver VM

Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity.

Nature cancer

Tsai KK, Huang SS, Northey JJ, Liao WY, Hsu CC, Cheng LH, Werner ME, Chuu CP, Chatterjee C, Lakins JN, Weaver VM

Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression.

Matrix biology plus

Metcalf KJ, Hayward MK, Berens E, Ironside AJ, Stashko C, Hwang ES, Weaver VM

NCI's publication affiliation conundrum: Reframing innovation to incentivize an equitable path for advocate representation.

Translational oncology

Samson S, Northey JJ, Acerbi I, Goga A, Flink CL, Weaver VM, LaBarge MA

Mechanobiology: forcing the second act.

Molecular biology of the cell

Weaver VM

Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis.

Genes & development

Rudnick JA, Monkkonen T, Mar FA, Barnes JM, Starobinets H, Goldsmith J, Roy S, Bustamante Eguiguren S, Weaver VM, Debnath J

Tissue mechanics in stem cell fate, development, and cancer.

Developmental cell

Hayward MK, Muncie JM, Weaver VM

Adhesion-mediated mechanosignaling forces mitohormesis.

Cell metabolism

Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saijo K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM

Single cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.

eLife

Hendley AM, Rao AA, Leonhardt L, Ashe S, Smith JA, Giacometti S, Peng XL, Jiang H, Berrios D, Pawlak M, Li LY, Lee J, Collisson EA, Anderson MS, Fragiadakis GK, Yeh JJ, Chun JY, Kim GE, Weaver VM, Hebrok M

Improving DCIS diagnosis and predictive outcome by applying artificial intelligence.

Biochimica et biophysica acta. Reviews on cancer

Hayward MK, Weaver VM

Leveraging microenvironmental synthetic lethalities to treat cancer.

The Journal of clinical investigation

Metcalf KJ, Alazzeh A, Werb Z, Weaver VM

Membrane Tension Locks In Pluripotency.

Cell stem cell

Muncie JM, Weaver VM

Derivation of a nuclear heterogeneity image index to grade DCIS.

Computational and structural biotechnology journal

Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC, Shelley Hwang E, Weaver VM

Proteoglycans as Mediators of Cancer Tissue Mechanics.

Frontiers in cell and developmental biology

Barkovskaya A, Buffone A, Žídek M, Weaver VM

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.

Nature materials

Maller O, Drain AP, Barrett AS, Borgquist S, Ruffell B, Zakharevich I, Pham TT, Gruosso T, Kuasne H, Lakins JN, Acerbi I, Barnes JM, Nemkov T, Chauhan A, Gruenberg J, Nasir A, Bjarnadottir O, Werb Z, Kabos P, Chen YY, Hwang ES, Park M, Coussens LM, Nelson AC, Hansen KC, Weaver VM

Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.

The Journal of clinical investigation

Northey JJ, Barrett AS, Acerbi I, Hayward MK, Talamantes S, Dean IS, Mouw JK, Ponik SM, Lakins JN, Huang PJ, Wu J, Shi Q, Samson S, Keely PJ, Mukhtar RA, Liphardt JT, Shepherd JA, Hwang ES, Chen YY, Hansen KC, Littlepage LE, Weaver VM

Zena Werb (1945-2020): Mourning the loss of a tissue microenvironment icon.

Proceedings of the National Academy of Sciences of the United States of America

Weaver VM, Bissell MJ

In Memoriam - Zena Werb 1945-2020.

Journal of mammary gland biology and neoplasia

Barcellos-Hoff MH, Weaver VM

Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix.

The Journal of clinical investigation

Jiang H, Torphy RJ, Steiger K, Hongo H, Ritchie AJ, Kriegsmann M, Horst D, Umetsu SE, Joseph NM, McGregor K, Pishvaian MJ, Blais EM, Lu B, Li M, Hollingsworth M, Stashko C, Volmar K, Yeh JJ, Weaver VM, Wang ZJ, Tempero MA, Weichert W, Collisson EA

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.

Science translational medicine

Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY

Zena Werb 1945-2020.

Nature cancer

Egeblad M, Coussens LM, Weaver VM

Fibrosis and cancer: A strained relationship.

Biochimica et biophysica acta. Reviews on cancer

Piersma B, Hayward MK, Weaver VM

A framework for advancing our understanding of cancer-associated fibroblasts.

Nature reviews. Cancer

Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics.

Journal of visualized experiments : JoVE

Muncie JM, Falcón-Banchs R, Lakins JN, Sohn LL, Weaver VM

Controlled modelling of human epiblast and amnion development using stem cells.

Nature

Zheng Y, Xue X, Shao Y, Wang S, Esfahani SN, Li Z, Muncie JM, Lakins JN, Weaver VM, Gumucio DL, Fu J

Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells.

Cell stem cell

Eliazer S, Muncie JM, Christensen J, Sun X, D'Urso RS, Weaver VM, Brack AS

Tissue mechanics, an important regulator of development and disease.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Ayad NME, Kaushik S, Weaver VM

The Extracellular Matrix Modulates the Metastatic Journey.

Developmental cell

Kai F, Drain AP, Weaver VM

Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.

eLife

Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC

A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.

Nature cell biology

Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM

Modeling Tissue Polarity in Context.

Journal of molecular biology

Tharp KM, Weaver VM

Fibronectin rescues estrogen receptor a from lysosomal degradation in breast cancer cells.

The Journal of cell biology

Sampayo RG, Toscani AM, Rubashkin MG, Thi K, Masullo LA, Violi IL, Lakins JN, Cáceres A, Hines WC, Coluccio Leskow F, Stefani FD, Chialvo DR, Bissell MJ, Weaver VM, Simian M

Compartment resolved proteomics reveals a dynamic matrisome in a biomechanically driven model of pancreatic ductal adenocarcinoma.

Journal of immunology and regenerative medicine

Barrett AS, Maller O, Pickup MW, Weaver VM, Hansen KC

The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate.

Current topics in developmental biology

Muncie JM, Weaver VM

New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.

Trends in cancer

Samson S, Northey JJ, Plaks V, Baas C, Dean I, LaBarge MA, Goga A, Van't Veer LJ, Weaver VM

Feeling Stress: The Mechanics of Cancer Progression and Aggression.

Frontiers in cell and developmental biology

Northcott JM, Dean IS, Mouw JK, Weaver VM

Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma.

Molecular cancer research : MCR

Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI

Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers.

Genes & development

Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z

Excess area dependent scaling behavior of nano-sized membrane tethers.

Physical biology

Ramakrishnan N, Sreeja KK, Roychoudhury A, Eckmann DM, Ayyaswamy PS, Baumgart T, Pucadyil T, Patil S, Weaver VM, Radhakrishnan R

A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression.

eLife

Woods EC, Kai F, Barnes JM, Pedram K, Pickup MW, Hollander MJ, Weaver VM, Bertozzi CR

Tissue Force Programs Cell Fate and Tumor Aggression.

Cancer discovery

Northey JJ, Przybyla L, Weaver VM

a5ß1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site.

Molecular biology of the cell

Miroshnikova YA, Rozenberg GI, Cassereau L, Pickup M, Mouw JK, Ou G, Templeman KL, Hannachi EI, Gooch KJ, Sarang-Sieminski AL, García AJ, Weaver VM

Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells.

Cancer immunology research

Pickup MW, Owens P, Gorska AE, Chytil A, Ye F, Shi C, Weaver VM, Kalluri R, Moses HL, Novitskiy SV

Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.

Cancer research

Salvador F, Martin A, López-Menéndez C, Moreno-Bueno G, Santos V, Vázquez-Naharro A, Santamaria PG, Morales S, Dubus PR, Muinelo-Romay L, López-López R, Tung JC, Weaver VM, Portillo F, Cano A

Cell and tissue mechanics: the new cell biology frontier.

Molecular biology of the cell

Weaver VM

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.

Science (New York, N.Y.)

Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF

Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy.

PloS one

Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver VM, Hwang DG, Chan MF

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.

Molecular biology of the cell

Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM

Tissue mechanics regulate brain development, homeostasis and disease.

Journal of cell science

Barnes JM, Przybyla L, Weaver VM

Force-dependent breaching of the basement membrane.

Matrix biology : journal of the International Society for Matrix Biology

Chang TT, Thakar D, Weaver VM

Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells.

The Journal of experimental medicine

Chan TS, Hsu CC, Pai VC, Liao WY, Huang SS, Tan KT, Yen CJ, Hsu SC, Chen WY, Shan YS, Li CR, Lee MT, Jiang KY, Chu JM, Lien GS, Weaver VM, Tsai KK

Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression.

Nature cell biology

Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM

Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions.

Integrative biology : quantitative biosciences from nano to macro

Ou G, Thakar D, Tung JC, Miroshnikova YA, Dufort CC, Gutierrez E, Groisman A, Weaver VM

Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer.

Annual review of cell and developmental biology

Przybyla L, Muncie JM, Weaver VM

Site-Specific Modulation of Charge Controls the Structure and Stimulus Responsiveness of Intrinsically Disordered Peptide Brushes.

Langmuir : the ACS journal of surfaces and colloids

Bhagawati M, Rubashkin MG, Lee JP, Ananthanarayanan B, Weaver VM, Kumar S

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Nature medicine

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM

Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness.

The Journal of cell biology

Le LT, Cazares O, Mouw JK, Chatterjee S, Macias H, Moran A, Ramos J, Keely PJ, Weaver VM, Hinck L

Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha.

Hepatology (Baltimore, Md.)

Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.

Cancer cell

Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R

Tumor-induced solid stress activates ß-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells.

BioEssays : news and reviews in molecular, cellular and developmental biology

Ou G, Weaver VM

Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors.

Molecular biology of the cell

Lin CH, Pelissier FA, Zhang H, Lakins J, Weaver VM, Park C, LaBarge MA

Monitoring developmental force distributions in reconstituted embryonic epithelia.

Methods (San Diego, Calif.)

Przybyla L, Lakins JN, Sunyer R, Trepat X, Weaver VM

STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma.

Cancer research

Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.

Integrative biology : quantitative biosciences from nano to macro

Acerbi I, Cassereau L, Dean I, Shi Q, Au A, Park C, Chen YY, Liphardt J, Hwang ES, Weaver VM

Fighting the force: Potential of homeobox genes for tumor microenvironment regulation.

Biochimica et biophysica acta

Northcott JM, Northey JJ, Barnes JM, Weaver VM

Tumor mechanics and metabolic dysfunction.

Free radical biology & medicine

Tung JC, Barnes JM, Desai SR, Sistrunk C, Conklin MW, Schedin P, Eliceiri KW, Keely PJ, Seewaldt VL, Weaver VM

A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype.

Journal of biotechnology

Cassereau L, Miroshnikova YA, Ou G, Lakins J, Weaver VM

The extracellular matrix modulates the hallmarks of cancer.

EMBO reports

Pickup MW, Mouw JK, Weaver VM

Extracellular matrix assembly: a multiscale deconstruction.

Nature reviews. Molecular cell biology

Mouw JK, Ou G, Weaver VM

The microenvironment matters.

Molecular biology of the cell

Weaver VM

Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate.

Cancer research

Rubashkin MG, Cassereau L, Bainer R, DuFort CC, Yui Y, Ou G, Paszek MJ, Davidson MW, Chen YY, Weaver VM

Multicellular architecture of malignant breast epithelia influences mechanics.

PloS one

Venugopalan G, Camarillo DB, Webster KD, Reber CD, Sethian JA, Weaver VM, Fletcher DA, El-Samad H, Rycroft CH

The cancer glycocalyx mechanically primes integrin-mediated growth and survival.

Nature

Paszek MJ, DuFort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver VM

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.

Cancer cell

Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R

Deconstructing signaling in three dimensions.

Biochemistry

Rubashkin MG, Ou G, Weaver VM

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.

Nature medicine

Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM

Rapid disorganization of mechanically interacting systems of mammary acini.

Proceedings of the National Academy of Sciences of the United States of America

Shi Q, Ghosh RP, Engelke H, Rycroft CH, Cassereau L, Sethian JA, Weaver VM, Liphardt JT

Cell biology. Strength under tension.

Science (New York, N.Y.)

Bainer R, Weaver V

Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-ß-deficient mouse mammary carcinomas.

Cancer research

Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL

Collagen architecture in pregnancy-induced protection from breast cancer.

Journal of cell science

Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P

Oncogenic targeting of BRM drives malignancy through C/EBPß-dependent induction of a5 integrin.

Oncogene

Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM

YAP forces fibroblasts to feel the tension.

Nature cell biology

Maller O, DuFort CC, Weaver VM

MT1-MMP-dependent control of skeletal stem cell commitment via a ß1-integrin/YAP/TAZ signaling axis.

Developmental cell

Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ

A physical sciences network characterization of non-tumorigenic and metastatic cells.

Scientific reports

Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH

Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer.

The American journal of pathology

Li CR, Su JJ, Wang WY, Lee MT, Wang TY, Jiang KY, Li CF, Hsu JM, Chen CK, Chen M, Jiang SS, Weaver VM, Tsai KK

Scanning angle interference microscopy reveals cell dynamics at the nanoscale.

Nature methods

Paszek MJ, DuFort CC, Rubashkin MG, Davidson MW, Thorn KS, Liphardt JT, Weaver VM

Morphogenesis: Laying down the tracks.

Nature materials

Cassereau L, DuFort CC, Weaver VM

The extracellular matrix: a dynamic niche in cancer progression.

The Journal of cell biology

Lu P, Weaver VM, Werb Z

Extracellular matrix degradation and remodeling in development and disease.

Cold Spring Harbor perspectives in biology

Lu P, Takai K, Weaver VM, Werb Z

In situ force mapping of mammary gland transformation.

Integrative biology : quantitative biosciences from nano to macro

Lopez JI, Kang I, You WK, McDonald DM, Weaver VM

Actomyosin-mediated cellular tension drives increased tissue stiffness and ß-catenin activation to induce epidermal hyperplasia and tumor growth.

Cancer cell

Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF

Balancing forces: architectural control of mechanotransduction.

Nature reviews. Molecular cell biology

DuFort CC, Paszek MJ, Weaver VM

Tumor microenvironment and progression.

Journal of surgical oncology

Dvorak HF, Weaver VM, Tlsty TD, Bergers G

The extracellular matrix at a glance.

Journal of cell science

Frantz C, Stewart KM, Weaver VM

Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis.

Journal of cellular physiology

Brown XQ, Bartolak-Suki E, Williams C, Walker ML, Weaver VM, Wong JY

Forcing form and function: biomechanical regulation of tumor evolution.

Trends in cell biology

Yu H, Mouw JK, Weaver VM

Dynamic interplay between the collagen scaffold and tumor evolution.

Current opinion in cell biology

Egeblad M, Rasch MG, Weaver VM

SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.

Journal of cellular physiology

Cohet N, Stewart KM, Mudhasani R, Asirvatham AJ, Mallappa C, Imbalzano KM, Weaver VM, Imbalzano AN, Nickerson JA

HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.

The Journal of clinical investigation

Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM

Biophysics. Enforcing order on signaling.

Science (New York, N.Y.)

Paszek M, Weaver V

Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate.

PLoS computational biology

Paszek MJ, Boettiger D, Weaver VM, Hammer DA

Matrix crosslinking forces tumor progression by enhancing integrin signaling.

Cell

Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM

Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension.

Molecular biology of the cell

Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA, Keely PJ

The tissue diagnostic instrument.

The Review of scientific instruments

Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Diez-Perez A, Alliston T, Weaver V, Lotz J

Multiscale modeling of form and function.

Science (New York, N.Y.)

Engler AJ, Humbert PO, Wehrle-Haller B, Weaver VM

CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Vasilatos SN, Broadwater G, Barry WT, Baker JC, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, Ibarra-Drendall C, Ostrander JH, D'Amato NC, Zalles C, Jirtle R, Weaver VM, Seewaldt VL

A tense situation: forcing tumour progression.

Nature reviews. Cancer

Butcher DT, Alliston T, Weaver VM

Biomechanical regulation of cell orientation and fate.

Oncogene

Lopez JI, Mouw JK, Weaver VM

Three-dimensional context regulation of metastasis.

Clinical & experimental metastasis

Erler JT, Weaver VM

A human breast cell model of preinvasive to invasive transition.

Cancer research

Rizki A, Weaver VM, Lee SY, Rozenberg GI, Chin K, Myers CA, Bascom JL, Mott JD, Semeiks JR, Grate LR, Mian IS, Borowsky AD, Jensen RA, Idowu MO, Chen F, Chen DJ, Petersen OW, Gray JW, Bissell MJ

Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion.

Journal of cell science

Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver VM, Chen CS, Assoian RK

Integrin-mediated signalling through the MAP-kinase pathway.

IET systems biology

Yee KL, Weaver VM, Hammer DA

Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures.

Annual review of pathology

Hebner C, Weaver VM, Debnath J

alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.

Journal of cell science

Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM

G'rab'bing the microenvironment for invasion.

Developmental cell

Weaver V, Werb Z

Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis.

The international journal of biochemistry & cell biology

Kass L, Erler JT, Dembo M, Weaver VM

The ultrastructure of MCF-10A acini.

Journal of cellular physiology

Underwood JM, Imbalzano KM, Weaver VM, Fischer AH, Imbalzano AN, Nickerson JA

Forcing the third dimension.

Cell

Boudreau N, Weaver V

Tensional homeostasis and the malignant phenotype.

Cancer cell

Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.

The Journal of biological chemistry

Yang C, Liu Y, Leskow FC, Weaver VM, Kazanietz MG

Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression.

Molecular biology of the cell

Cowden Dahl KD, Robertson SE, Weaver VM, Simon MC

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.

Cell motility and the cytoskeleton

Yeung T, Georges PC, Flanagan LA, Marg B, Ortiz M, Funaki M, Zahir N, Ming W, Weaver V, Janmey PA

The tension mounts: mechanics meets morphogenesis and malignancy.

Journal of mammary gland biology and neoplasia

Paszek MJ, Weaver VM

Watch thy neighbor: cancer is a communal affair.

Journal of cell science

Weaver VM, Gilbert P

Death in the third dimension: apoptosis regulation and tissue architecture.

Current opinion in genetics & development

Zahir N, Weaver VM

Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.

The Journal of cell biology

Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM

Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin.

Journal of cell science

Russell AJ, Fincher EF, Millman L, Smith R, Vela V, Waterman EA, Dey CN, Guide S, Weaver VM, Marinkovich MP

The tissue microenvironment as an epigenetic tumor modifier.

Methods in molecular biology (Clifton, N.J.)

Unger M, Weaver VM

The organizing principle: microenvironmental influences in the normal and malignant breast.

Differentiation; research in biological diversity

Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW

Lack of specificity of trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foods.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Weaver VM, Buckley T, Groopman JD

E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture.

Cancer research

Spancake KM, Anderson CB, Weaver VM, Matsunami N, Bissell MJ, White RL

Constitutive expression of Heregulin induces apoptosis in an erbB-2 overexpressing breast cancer cell line SKBr-3.

International journal of oncology

Guerra-Vladusic FK, Scott G, Weaver V, Vladusic EA, Tsai MS, Benz CC, Lupu R

Tissue structure, nuclear organization, and gene expression in normal and malignant breast.

Cancer research

Bissell MJ, Weaver VM, Lelièvre SA, Wang F, Petersen OW, Schmeichel KL

Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology.

Proceedings of the National Academy of Sciences of the United States of America

Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ

Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus.

Proceedings of the National Academy of Sciences of the United States of America

Lelièvre SA, Weaver VM, Nickerson JA, Larabell CA, Bhaumik A, Petersen OW, Bissell MJ

Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype.

Journal of mammary gland biology and neoplasia

Schmeichel KL, Weaver VM, Bissell MJ

Differentiation and cancer in the mammary gland: shedding light on an old dichotomy.

Advances in cancer research

Petersen OW, Rønnov-Jessen L, Weaver VM, Bissell MJ

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies.

The Journal of cell biology

Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ

Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes.

Journal of cell science

Weaver VM, Carson CE, Walker PR, Chaly N, Lach B, Raymond Y, Brown DL, Sikorska M

The development of a functionally relevant cell culture model of progressive human breast cancer.

Seminars in cancer biology

Weaver VM, Howlett AR, Langton-Webster B, Petersen OW, Bissell MJ

Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Weaver VM, Lach B, Walker PR, Sikorska M