Home / Team / Chelsea Bahney, PhD
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Chelsea Bahney, PhD

Associate Adjunct Professor
Orthopaedic Surgery
+1 628 206-5362

The overall goal of my research is to develop novel therapies for the treatment of musculoskeletal diseases and injuries. Specifically, I believe we can drive improved tissue regeneration by recapitulating the normal sequences of development and repair. To accomplish this “Developmental Engineering” approach our laboratory utilizes a cross-disciplinary tools combining biologically modified synthetic polymers, stem cell biology, and murine models of orthopaedic injuries. The long-term goal of our research is to solve problems that will have a direct and significant impact on human health.

Current Projects:

(1) Tissue engineering strategies to promote endochondral bone regeneration
(2) Transdifferentiation of cartilage to bone during fracture repair and osteoarthritis
(3) The role of the nerve in fracture repair
(4) Polytraumatic Injuries: How brain trauma influences fracture healing
(5) Impedance sensors to monitor fracture healing

Publications: 

Combination Therapy of Losartan and Fisetin Reduces Senescence and Enhances Osteogenesis in Human Bone Marrow–Derived Mesenchymal Stem Cells.

Journal of Tissue Engineering and Regenerative Medicine

Haruki Nishimura, Yoichi Murata, Michael T. Mullen, Kohei Yamaura, Jacob Singer, Charles Huard, Dane R. G. Lind, William S. Hambright, Chelsea S. Bahney, Marc J. Philippon, Johnny Huard

Polytrauma impairs fracture healing accompanied by increased persistence of innate inflammatory stimuli and reduced adaptive response.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Saiz AM, Rahmati M, Gresham RCH, Baldini TD, Burgan J, Lee MA, Osipov B, Christiansen BA, Khassawna TE, Wieland DCF, Marinho AL, Blanchet C, Czachor M, Working ZM, Bahney CS, Leach JK

Murine Progeria Model Exhibits Delayed Fracture Healing with Dysregulated Local Immune Response.

bioRxiv : the preprint server for biology

Duke VR, Philippon MJ, Lind DRG, Kasler H, Yamaura K, Huard M, Czachor M, Hollenbeck J, Brown J, Garcia A, Fukase N, Marcucio RS, Nelson AL, Hambright WS, Snapper DM, Huard J, Bahney CS

β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model.

Bioactive materials

Nelson AL, Mancino C, Gao X, Choe JA, Chubb L, Williams K, Czachor M, Marcucio R, Taraballi F, Cooke JP, Huard J, Bahney C, Ehrhart N

Clinical validation of C12FDG as a marker associated with senescence and osteoarthritic phenotypes.

Aging cell

Hambright WS, Duke VR, Goff AD, Goff AW, Minas LT, Kloser H, Gao X, Huard C, Guo P, Lu A, Mitchell J, Mullen M, Su C, Tchkonia T, Espindola Netto JM, Robbins PD, Niedernhofer LJ, Kirkland JL, Bahney CS, Philippon M, Huard J

Preclinical models of orthopaedic trauma: Orthopaedic Research Society (ORS) and Orthopaedic Trauma Association (OTA) symposium 2022.

OTA international : the open access journal of orthopaedic trauma

Wise PM, Saiz AM, Haller J, Wenke JC, Schaer T, Schneider P, Morshed S, Bahney CS

Evaluating the Morphology of Unique Superficial Fissured Cartilage Lesions at the Femoral Head-Neck Junction in Patients with Femoroacetabular Impingement Syndrome.

Orthopaedic Journal of Sports Medicine

Yamaura K, Nishimura H, Ruzbarsky JJ, Kuhns BD, Mullen MT, Duke VR, O'Hara KM, Brown JM, Comfort SM, Hambright WS, Bahney CS, Huard J, Philippon MJ

Mineral coated microparticles doped with fluoride and complexed with mRNA prolong transfection in fracture healing.

Frontiers in bioengineering and biotechnology

Nelson AL, Fontana G, Chubb L, Choe J, Williams K, Regan D, Huard J, Murphy W, Ehrhart N, Bahney C

Compliant substrates mitigate the senescence associated phenotype of stress induced mesenchymal stromal cells.

Journal of biomedical materials research. Part A

Gresham RCH, Filler AC, Fok SW, Czachor M, Schmier N, Pearson C, Bahney C, Leach JK

Engineered Decellularized Tendon Matrix Putty Preserves Native Tendon Bioactivity to Promote Cell Proliferation and Enthesis Repair.

Journal of Tissue Engineering and Regenerative Medicine

Anna-Laura Nelson, Kelsey M. O’Hara, Philip C. Nolte, Naomasa Fukase, Yoichi Murata, Anna-Katharina Nolte, Johnny Huard, David L. Bernholt, Peter J. Millett, Chelsea S. Bahney

A Systemic and Local Comparison of Senescence in an Acute Anterior Cruciate Ligament Injury-A Pilot Case Series.

Life (Basel, Switzerland)

Waltz RA, Whitney KE, Duke VR, Kloser H, Huard C, Provencher MT, Philippon MJ, Bahney C, Godin JA, Huard J

Therapeutic potential of senolytic agent quercetin in osteoarthritis: A systematic review and meta-analysis of preclinical studies.

Ageing research reviews

Yamaura K, Nelson AL, Nishimura H, Rutledge JC, Ravuri SK, Bahney C, Philippon MJ, Huard J

Encapsulation of ß-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair.

Frontiers in bioengineering and biotechnology

Rivera KO, Cuylear DL, Duke VR, O'Hara KM, Zhong JX, Elghazali NA, Finbloom JA, Kharbikar BN, Kryger AN, Miclau T, Marcucio RS, Bahney CS, Desai TA

The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24-/- Progeria Mouse Model.

Journal of osteoporosis

Hambright WS, Mu X, Gao X, Guo P, Kawakami Y, Mitchell J, Mullen M, Nelson AL, Bahney C, Nishimura H, Hellwinkel J, Eck A, Huard J

Sustained-release losartan from peptide nanofibers promotes chondrogenesis.

Frontiers in bioengineering and biotechnology

Yamaura K, Sather NA, Metlushko A, Nishimura H, Pavlovic RZ, Hambright S, Ravuri SK, Philippon MJ, Stupp SI, Bahney CS, Huard J

Altered early immune response after fracture and traumatic brain injury.

Frontiers in immunology

Haffner-Luntzer M, Weber B, Morioka K, Lackner I, Fischer V, Bahney C, Ignatius A, Kalbitz M, Marcucio R, Miclau T

Macromolecular crowding and decellularization method increase the growth factor binding potential of cell-secreted extracellular matrices.

Frontiers in bioengineering and biotechnology

Fok SW, Gresham RCH, Ryan W, Osipov B, Bahney C, Leach JK

The effects of losartan or angiotensin II receptor antagonists on cartilage: a systematic review.

Osteoarthritis and cartilage

Yamaura K, Nelson AL, Nishimura H, Rutledge JC, Ravuri SK, Bahney C, Philippon MJ, Huard J

Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel.

Science advances

Li J, Sudiwala S, Berthoin L, Mohabbat S, Gaylord EA, Sinada H, Cruz Pacheco N, Chang JC, Jeon O, Lombaert IMA, May AJ, Alsberg E, Bahney CS, Knox SM

Cellular expansion of MSCs: Shifting the regenerative potential.

Aging cell

Miclau K, Hambright WS, Huard J, Stoddart MJ, Bahney CS

Mechanical strain drives exosome production, function, and miRNA cargo in C2C12 muscle progenitor cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Mullen M, Williams K, LaRocca T, Duke V, Hambright WS, Ravuri SK, Bahney CS, Ehrhart N, Huard J

A Shifting Paradigm: Transformation of Cartilage to Bone during Bone Repair.

Journal of dental research

Marcucio RS, Miclau T, Bahney CS

The effects of fisetin on bone and cartilage: A systematic review.

Pharmacological research

Yamaura K, Nelson AL, Nishimura H, Rutledge JC, Ravuri SK, Bahney C, Philippon MJ, Huard J

Therapeutic approaches to activate the canonical Wnt pathway for bone regeneration.

Journal of Tissue Engineering and Regenerative Medicine

Nelson AL, Fontana G, Miclau E, Rongstad M, Murphy W, Huard J, Ehrhart N, Bahney C

Wireless Measurements Using Electrical Impedance Spectroscopy to Monitor Fracture Healing.

Sensors (Basel, Switzerland)

Fukase N, Duke VR, Lin MC, Stake IK, Huard M, Huard J, Marmor MT, Maharbiz MM, Ehrhart NP, Bahney CS, Herfat ST

Poster 217: Local and Systemic Comparison of Senescent Profiles in Acute Knee Injury.

Orthopaedic Journal of Sports Medicine

Kaitlyn Whitney, Heidi Kloser, Charles Huard, Chelsea Bahney, Matthew Provencher, Jonathan Godin, Johnny Huard, Robert Waltz

Bone turnover markers as surrogates of fracture healing after intramedullary fixation of tibia and femur fractures.

Bone & joint research

Stewart CC, O'Hara NN, Bzovsky S, Bahney CS, Sprague S, Slobogean GP, Vita-Shock Investigators

Collagen X Longitudinal Fracture Biomarker Suggests Staged Fixation in Tibial Plateau Fractures Delays Rate of Endochondral Repair.

Journal of orthopaedic trauma

Working ZM, Peterson D, Lawson M, O'Hara K, Coghlan R, Provencher MT, Friess DM, Johnstone B, Miclau T, Bahney CS

The intersection of fracture healing and infection: Orthopaedics research society workshop 2021.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Hellwinkel JE, Working ZM, Certain L, García AJ, Wenke JC, Bahney CS

A timeseries analysis of the fracture callus extracellular matrix proteome during bone fracture healing.

Journal of life sciences (Westlake Village, Calif.)

Erickson CB, Hill R, Pascablo D, Kazakia G, Hansen K, Bahney C

Revisiting Arnoczky: Measuring the Microvascular Anatomy of Young Adult Menisci.

Arthroscopy The Journal of Arthroscopic and Related Surgery

Matthew D. Crawford, Justin Hellwinkel, Zachary Aman, Ramesses Akamefula, Thomas Singleton, Chelsea Bahney, Robert LaPrade

Local injections of ß-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion.

Scientific reports

Rivera KO, Russo F, Boileau RM, Tomlinson RE, Miclau T, Marcucio RS, Desai TA, Bahney CS

Chondrocyte-to-osteoblast transformation in mandibular fracture repair.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Wong SA, Hu DP, Slocum J, Lam C, Nguyen M, Miclau T, Marcucio RS, Bahney CS

Microvascular Anatomy and Intrinsic Gene Expression of Menisci From Young Adults.

The American journal of sports medicine

Crawford MD, Hellwinkel JE, Aman Z, Akamefula R, Singleton JT, Bahney C, LaPrade RF

The Life of a Fracture: Biologic Progression, Healing Gone Awry, and Evaluation of Union.

JBJS reviews

Hellwinkel JE, Miclau T, Provencher MT, Bahney CS, Working ZM

A quantitative serum biomarker of circulating collagen X effectively correlates with endochondral fracture healing.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Working ZM, Morris ER, Chang JC, Coghlan RF, Johnstone B, Miclau T, Horton WA, Bahney CS

The platelet-rich plasma and mesenchymal stem cell milieu: A review of therapeutic effects on bone healing.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Liebig BE, Kisiday JD, Bahney CS, Ehrhart NP, Goodrich LR

Exosome Production and Regenerative Potential is Influenced by Mechanical Stimulus and Cell Origin.

The FASEB Journal

Michael Mullen, Chelsea Bahney, Sudheer Ravuri, Johnny Huard, Nicole Ehrhart

Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma.

Scientific reports

Morioka K, Marmor Y, Sacramento JA, Lin A, Shao T, Miclau KR, Clark DR, Beattie MS, Marcucio RS, Miclau T, Ferguson AR, Bresnahan JC, Bahney CS

Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling.

Proceedings of the National Academy of Sciences of the United States of America

Haffner-Luntzer M, Foertsch S, Fischer V, Prystaz K, Tschaffon M, Mödinger Y, Bahney CS, Marcucio RS, Miclau T, Ignatius A, Reber SO

Smart bone plates can monitor fracture healing.

Scientific reports

Lin MC, Hu D, Marmor M, Herfat ST, Bahney CS, Maharbiz MM

Cellular biology of fracture healing.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Bahney CS, Zondervan RL, Allison P, Theologis A, Ashley JW, Ahn J, Miclau T, Marcucio RS, Hankenson KD

A degradation fragment of type X collagen is a real-time marker for bone growth velocity.

Coghlan RF, Oberdorf JA, Sienko S, Aiona MD, Boston BA, Connelly KJ, Bahney C, LaRouche J, Almubarak SM, Coleman DT, Girkontaite I, von der Mark K, Lunstrum GP, Horton WA

Origin of Reparative Stem Cells in Fracture Healing.

Current osteoporosis reports

Bragdon BC, Bahney CS

Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair-A New Frontier for Developmental Engineering.

Frontiers in bioengineering and biotechnology

Wong SA, Rivera KO, Miclau T, Alsberg E, Marcucio RS, Bahney CS

A degradation fragment of type X collagen is a real-time marker for bone growth velocity.

Science translational medicine

Coghlan RF, Oberdorf JA, Sienko S, Aiona MD, Boston BA, Connelly KJ, Bahney C, LaRouche J, Almubarak SM, Coleman DT, Girkontaite I, von der Mark K, Lunstrum GP, Horton WA

Using impedance to track fracture healing rates in mice in vivo: A pilot study.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Lin MC, Hu D, Yang F, Herfat ST, Bahney CS, Marmor M, Maharbiz MM

New opportunities for fracture healing detection: Impedance spectroscopy measurements correlate to tissue composition in fractures.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lin MC, Yang F, Herfat ST, Bahney CS, Marmor M, Maharbiz MM

Fortifying the Bone-Implant Interface Part 1: An In Vitro Evaluation of 3D-Printed and TPS Porous Surfaces.

International journal of spine surgery

MacBarb RF, Lindsey DP, Bahney CS, Woods SA, Wolfe ML, Yerby SA

Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing?

Frontiers in cell and developmental biology

Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T

Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes.

Development (Cambridge, England)

Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS

Accelerating the pace of discovery in orthopaedic research: A vision toward team science.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Bahney CS, Bruder SP, Cain JD, Keyak JH, Killian ML, Shapiro IM, Jones LC

Matrix Reloaded: Devitalized Cartilage as a Functional Extracellular Niche to Promote Osteogenesis and Angiogenesis.

The FASEB Journal

Jaselle M Perry, Donna M Poscablo, Brandon T Gaston, Diane P Hu, Theodore Miclau, Karen L Christman, Ralph S Marcucio, Chelsea S Bahney

Trans differentiation of Chondrocytes to Osteoblasts during Endochondral Ossification in the Healing Mandible.

The FASEB Journal

Sarah Anne Wong, Diane Hu, Theodore Miclau, Chelsea Bahney, Ralph Marcucio

Transdifferentiation of Chondrocytes to Osteoblasts during Bone Fracture Healing.

The FASEB Journal

Ralph Marcucio, Diane Hu, Frank Yang, Chelsea Bahney, Theodore Miclau

Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes.

Tissue engineering. Part A

Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC

Inflammation, Bone Healing, and Anti-Inflammatory Drugs: An Update.

Journal of orthopaedic trauma

Giannoudis PV, Hak D, Sanders D, Donohoe E, Tosounidis T, Bahney C

Stem Cell Therapies in Orthopaedic Trauma.

Journal of orthopaedic trauma

Marcucio RS, Nauth A, Giannoudis PV, Bahney C, Piuzzi NS, Muschler G, Miclau T

Tissue engineering strategies for promoting vascularized bone regeneration.

Bone

Almubarak S, Nethercott H, Freeberg M, Beaudon C, Jha A, Jackson W, Marcucio R, Miclau T, Healy K, Bahney C

Review Article

The multifaceted role of the vasculature in endochondral fracture repair

Bahney, CS; Hu, DP; Miclau, T; Marcucio, RS

The multifaceted role of the vasculature in endochondral fracture repair.

Frontiers in endocrinology

Bahney CS, Hu DP, Miclau T, Marcucio RS

Impedance spectroscopy to monitor fracture healing.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Lin MC, Herfat ST, Bahney CS, Marmor M, Maharbiz MM

Endochondral bone tissue engineering: using cartilage to drive vascularized bone regeneration (87.6).

The FASEB Journal

Chelsea Bahney, Amit Jha, Diane Hu, Aaron Taylor, Hayley Britz, Benedikt Hallgrimsson, Ted Miclau, Ralph Marcucio

Therapeutic delivery of placental stem cells to modulate vasculature and promote fracture repair (342.6).

The FASEB Journal

Chelsea Bahney, Aaron Taylor, Ali Sadat, Kathryn Tormos, Ted Miclau, Emin Maltepe, Ralph Marcucio

Transdifferentiation of hypertrophic chondrocytes during endochondral bone repair by activation of pluripotent stem cell programs (216.1).

The FASEB Journal

Chelsea Bahney, Diane Hu, Federico Ferro, Aaron Taylor, Ted Miclau, Ralph Marcucio

9 Cartilage grafts for bone repair and regeneration.

Bone Substitute Biomaterials

C.S. Bahney, R.S. Marcucio

Contributor contact details.

Bone Substitute Biomaterials

K.K. Mallick, S. Sprio, M. Sandri, M. Iafisco, A. Ruffini, S. Minardi, A. Tampieri, P. Bhattacharya, G.H. van Lenthe, E.B. Hunziker, T.J. Blokhuis, V. Guarino, M.G. Raucci, A. Ronca, V. Cirillo, L. Ambrosio, K.K. Mallick, J. Winnett, A. Bansiddhi, D.C. Dunand, G.C. Wang, Z.F. Lu, H. Zreiqat, C.S. Bahney, R.S. Marcucio, J. Venkatesan, S.K. Kim, L. Grøndahl, C.S. Goonasekera, K.S. Jack, S.A. Clarke, P. Walsh

Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Bahney CS, Hu DP, Taylor AJ, Ferro F, Britz HM, Hallgrimsson B, Johnstone B, Miclau T, Marcucio RS

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects.

Journal of Visualized Experiments

Yan-yiu Yu, Chelsea Bahney, Diane Hu, Ralph S. Marcucio, Theodore Miclau, III

Tissue engineering bone by recapitulating developmental and repair programs offers improved biological outcomes.

The FASEB Journal

Chelsea Shields Bahney, Diane Hu, Theodore Miclau, Ralph Marcucio

Therapeutic potential of stem cells in orthopedics.

Indian journal of orthopaedics

Bahney CS, Miclau T

Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels.

European cells & materials

Bahney CS, Lujan TJ, Hsu CW, Bottlang M, West JL, Johnstone B

A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Bahney CS, Hsu CW, Yoo JU, West JL, Johnstone B

A novel bioreactor for the dynamic stimulation and mechanical evaluation of multiple tissue-engineered constructs.

Tissue engineering. Part C, Methods

Lujan TJ, Wirtz KM, Bahney CS, Madey SM, Johnstone B, Bottlang M

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