Christopher Hernandez, PhD | Health Innovation via Engineering

Professor In Res

Orthopaedic Surgery

I am a mechanical engineer and bioengineer. My laboratory studies interactions between microbes, musculoskeletal tissues and materials. We are currently studying the effects of the gut microbiome on the musculoskeletal system and the success of orthopaedic surgery. Additionally we are studying mechanobiology of bacteria and advancing the new field of Engineered Living Materials.

Publications

Microbiome-induced Increases and Decreases in Bone Matrix Strength can be Initiated After Skeletal Maturity.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Liu C, Cyphert EL, Stephen SJ, Wang B, Morales AL, Nixon JC, Natsoulas NR, Garcia M, Carmona PB, Vill AC, Donnelly E, Brito IL, Vashishth D, Hernandez CJ

Determining the Young's Modulus of the Bacterial Cell Envelope.

ACS biomaterials science & engineering

Lee J, Jha K, Harper CE, Zhang W, Ramsukh M, Bouklas N, Dörr T, Chen P, Hernandez CJ

Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway.

Scientific reports

Harper CE, Zhang W, Lee J, Shin JH, Keller MR, van Wijngaarden E, Chou E, Wang Z, Dörr T, Chen P, Hernandez CJ

Mechanical stress compromises multicomponent efflux complexes in bacteria.

Proceedings of the National Academy of Sciences of the United States of America

Genova LA, Roberts MF, Wong YC, Harper CE, Santiago AG, Fu B, Srivastava A, Jung W, Wang LM, Krzeminski L, Mao X, Sun X, Hui CY, Chen P, Hernandez CJ

Bone-inspired microarchitectures achieve enhanced fatigue life.

Proceedings of the National Academy of Sciences of the United States of America

Torres AM, Trikanad AA, Aubin CA, Lambers FM, Luna M, Rimnac CM, Zavattieri P, Hernandez CJ

Disruption of the Gut Microbiome Increases the Risk of Periprosthetic Joint Infection in Mice.

Clinical orthopaedics and related research

Hernandez CJ, Yang X, Ji G, Niu Y, Sethuraman AS, Koressel J, Shirley M, Fields MW, Chyou S, Li TM, Luna M, Callahan RL, Ross FP, Lu TT, Brito IL, Carli AV, Bostrom MPG

Alterations to the Gut Microbiome Impair Bone Strength and Tissue Material Properties.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Guss JD, Horsfield MW, Fontenele FF, Sandoval TN, Luna M, Apoorva F, Lima SF, Bicalho RC, Singh A, Ley RE, van der Meulen MC, Goldring SR, Hernandez CJ

Links Between the Microbiome and Bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Hernandez CJ, Guss JD, Luna M, Goldring SR

Material heterogeneity in cancellous bone promotes deformation recovery after mechanical failure.

Proceedings of the National Academy of Sciences of the United States of America

Torres AM, Matheny JB, Keaveny TM, Taylor D, Rimnac CM, Hernandez CJ

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